Stereochemical Control of Photo-reactions within Zeolites

该研究项目的目标是开发基于沸石/手性催化剂组合的不对称光化学反应。 这是基于沸石中可以包含多于一种分子或类型的客体分子的事实。 在不存在容易获得的手性沸石的情况下，通过在沸石内包括手性有机分子将产生不对称环境。 研究的光反应包括二烯的齐默尔曼（二-π-甲烷）重排、酮的诺里什-杨（II型）反应、β-γ-不饱和烯酮的氧杂-二-π-甲烷重排和多烯的电环化。有了这个奖项，有机和大分子化学计划支持杜兰大学教授Vaidyanathan Ramamurthy的研究。 Ramamurthy教授研究光激活化学反应，这些反应发生在某些天然和人造矿物（称为沸石）的分子尺度孔隙内。 通过允许某种分子与反应物分子一起沿着进入沸石空腔，可以更好地控制反应期间的进行。 通过这种方式，可以获得用于制药工业的高附加值物质。 此外，我们对分子与沸石相互作用的方式以及这种相互作用如何影响随后的光化学的理解将得到增强。

This research project has as its goal the development of asymmetric photochemical reactions based on a zeolite / chiral catalyst combination. This is based on the fact that more than one molecule or type of guest molecule can be included within a zeolite. In the absence of readily available chiral zeolites, an asymmetric environment will be created by including chiral organic molecules within zeolites. Photoreactions to be studied include the Zimmerman (di-pi-methane) rearrangement of dienes, the Norrish-Yang (Type II) reaction of ketones, oxa-di-pi-methane rearrangement of beta-gamma-unsaturated enones, and electrocyclization of polyenes.With this Award, the Organic and Macromolecular Chemistry Program supports the research of Professor Vaidyanathan Ramamurthy of Tulane University. Professor Ramamurthy studies light-activated chemical reactions that take place inside the molecular scale pores of certain natural and man-made minerals called zeolites. By permitting a certain kind of molecule to enter the zeolite cavity along with the reactant molecule, it may be possible to gain better control over the goings-on during the reaction. In this way, high value-added substances of use for the pharmaceutical industry might be accessed. Further, our understanding of the way in which molecules interact with zeolites and how this interaction affects the subsequent photochemistry will be enhanced.