National High Field FT-ICR Mass Spectroscopy Facility

在化学研究仪器和设施(CRIF)计划的支持下，佛罗里达州立大学(FSU)的Alan G.Marshal、Christopher L.Hendrickson和Mark R.Emmett以及佛罗里达大学的John R.Eyler将继续操作位于FSU国家强磁场实验室(NHMFL)的傅立叶变换离子回旋共振/质谱仪(FT-ICR/MS)设备。将在下一个赠款期间使用FT-ICR/MS设施进行的研究包括：蛋白质的同位素解析；石油原料等复杂混合物的高精度质谱学；环境混合物的分析(漏油；生物修复)；以及探索使用磁场控制离子/分子反应的研究。设计和开发工作将侧重于将基质辅助激光解吸/电离FT-ICR/MS仪器安装到11特斯拉磁体中；使用17特斯拉磁体安装电喷雾电离FT-ICR/MS仪器；以及开发质量选择性外部离子积累，这将导致灵敏度和动态范围的改善。PIS还计划进一步开发使用FT-ICR的质量选择气相分子离子的光学光谱。他们将继续向外部用户社区提供接触和服务，包括为来访的研究生和博士后提供资金；为非FT-ICR MS专家和工业企业提供大规模分析。将继续开展教育和外联工作，例如定期出版通讯，组织两年一次的会议，并让本科生参加暑期研究项目。佛罗里达州立大学的傅里叶变换离子回旋共振/质谱分析设备是一项独特的全国性资源，为美国学术和工业机构的化学家和生化学家提供最先进的分析仪器和质谱分析。在该设施中进行的研究有助于更好地了解生物分子的行为，以及生物分子、环境化学中重要的复杂混合物和石油产品的结构。该设施还为培训和教育大量研究生和博士后研究员使用先进的质谱学做出了重要贡献。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, Alan G. Marshal, Christopher L. Hendrickson and Mark R. Emmett of Florida State University (FSU) and John R. Eyler of the University of Florida will continue to operate the Fourier-Transform Ion Cyclotron Resonance/Mass Spectrometry (FT-ICR/MS) Facility, housed in the National High Magnetic Field Laboratory (NHMFL) at FSU. Studies to be carried out using the FT-ICR/MS facility during the next grant period include isotopic resolution of proteins; highly accurate mass spectra of complex mixtures such as petroleum feedstocks; analysis of environmental mixtures (oil spills; bioremediation); and studies exploring the use of magnetic fields to control ion/molecule reactions. Design and development efforts will focus on the installation of a matrix-assisted laser desorption/ionization (MALDI) FT-ICR/MS instrument into an 11 tesla magnet; installation of an electrospray ionization (ESI) FT-ICR/MS instrument using a 17 tesla magnet; and the development of mass-selective external ion accumulation, which should lead to improvements in sensitivity and dynamic range. The PIs also plan further development of optical spectroscopy of mass-selected gas phase molecular ions using FT-ICR. They will continue to provide access and services to the external user community, including provision of funds for visiting graduate students and postdocs; and mass analysis for non-FT-ICR MS experts and industrial concerns. Education and outreach efforts will continue, such as regular publication of newsletters, organization of biennial conferences, and participation of undergraduates in summer research programs. The Fourier Transform-Ion Cyclotron Resonance/Mass Spectrometry Facility at Florida State University is a unique national resource that provides state-of-the-art analytical instrumentation and mass spectral analysis to chemists and biochemists in US academic and industrial institutions. Studies that are carried out at the facility lead to a better understanding of the behavior of biomolecules, and the structure of biomolecules, complex mixtures important in environmental chemistry, and petroleum products. This facility also makes an important contribution to the training and education of significant numbers of graduate students and postdoctoral fellows in the use of advanced mass spectrometry.