Computational Algorithms for Multidimensional Biological Image Organization

两百多年来，显微镜一直是生物学研究的一种广泛使用的工具，但人们对显微镜的兴趣和发展在这些年里起起伏伏。然而，在过去的几年里，基因组学取得了非凡的进步，帮助识别了细胞和有机体的更多物理成分，从而在确定这些部分如何作为一个活的整体发挥作用方面产生了新的挑战，这推动了对显微镜的新需求。该项目开发了一个集成软件套件，用于捕获、存档、可视化、分析和分发胚胎发育的多焦平面、时间推移(4-D)显微记录。先进的可视化辅助工具，包括漫游空间和时间、3-D渲染和任意平面切片，有助于感知复杂的结构动态。一个全面的注释系统可以在数据库中建立广泛标记的典型发育序列，从而为胚胎学学生提供强大的教育资源。网站：http://www.loci.wisc.edu/cambio

The microscope has been a widely used tool of biological research for over two hundred years, but interest and developments in microscopy have waxed and waned over the years. Extraordinary advances in genomics over the past few years, however, which have helped identify more physical components of cells and organisms thus creating a new challenge in determining how these parts function together as a living ensemble, have fueled a new demand for microscopy. This project develops an integrated software suite that is used to capture, archive, visualize, analyze and distribute multifocal plane, time-lapse (4-D) microscopic recordings of embryonic development. Advanced visualization aids including roaming space and time, 3-D rendering and arbitrary plane slicing facilitates perception of complex structural dynamics. A comprehensive annotation system enables extensively labeled canonical developmental sequences to be established in a database thereby providing a powerful educational resource for students of embryology.Web site: http://www.loci.wisc.edu/cambio