Practical Organic Oxidations in Water (TSE 99-A)

这项研究的重点是1，2-杂原子官能化，在水中，烯烃，主要是与锇和钨催化剂。 烯烃氧化产生的产物将转化为“弹簧加载”亲电体，其可以与各种亲核试剂反应，但不与水反应，并且不需要来自苛刻试剂或复杂催化剂的指导。 机械的考虑表明，使用水作为溶剂应改善这些过程。 凭借EPA/NSF环境研究伙伴关系的可持续环境技术组成部分的这一奖项，有机和高分子化学计划以及多学科活动办公室正在支持K博士的研究。斯克里普斯研究所化学系的巴里夏普勒斯说。Sharpless教授将专注于开发水中烯烃氧化反应的方法，以及使用氧化产物构建有用分子的水相方法。 这项工作对制药工业具有潜在的影响，其中高度可靠的水相反应应可用于制备具有生物相关功能的复杂结构。

The focus of this research is the 1,2-heteroatom functionalization, in water, of olefins, primarily with osmium and tungsten catalysts. The resulting products of olefin oxidation will be converted to "spring-loaded" electrophiles that can react with a wide variety of nucleophiles, but not with water, and without the need for direction from harsh reagents or complex catalysts. Mechanistic considerations reveal that using water as solvent should improve these processes. With this award in the Technology for Sustainable Environment component of the EPA/NSF Partnership for Environmental Research, the Organic and Macromolecular Chemistry Program and the Office of Multidisciplinary Activities are supporting the research of Dr. K. Barry Sharpless of the Department of Chemistry at the Scripps Research Institute. Professor Sharpless will focus his work on developing methodology for olefin oxidation reactions in water and on aqueous-phase methods for the use of oxidized products to construct useful molecules. The work has potential impact on the pharmaceutical industry wherein highly reliable, aqueous-phase reactions should be available for the preparation of complex structures bearing biologically relevant functionality.