SGER: Piezoelectric Cantilevers for Nanoscale Biosensing

ilhan Aksay，普林斯顿大学该提案旨在澄清基本过程，这将允许设计和建造一类新的微传感器。这些将结合压电微悬臂、纳米结构涂层（如纳米多孔二氧化硅）和生物探测器。它们的灵敏度将比现有的压电式传感器高出约100倍。然后，PI们对他们认为在设计师能够依赖可靠的通用信息之前应该探索的关键基本问题进行了非常详细的讨论：1)通过溶胶/凝胶化学和软光刻技术生产缩小尺寸的微悬臂阵列，作为一种从给定样品中收集更多同步和实时生物特性（例如血液）的方法。预计二氧化硅孔隙度的增强作用是主要的（可达500 m2/g）。一个特别感兴趣的应用将是，除其他外，生物传感器微阵列技术在体内的情况下。2)提案剩余的大部分内容涉及这些诊断技术关键组成部分的技术现状和建议的研究方向：传感器性能（压电微悬臂和纳米结构涂层），陶瓷与石英，微制造，建模和尺寸效应，纳米多孔介质中的生物分子行为。

AbstractCTS-0003882Ilhan Aksay, Princeton UniversityThis proposal aims at clearing the fundamental processes which will permit the design and construction of a new class of microsensors. These will combine piezoelectric microcantilevers, nanostructured coatings (e.g. nanoporous silica), and biological detectors. Their sensitivity should outperform existing piezoactive sensors by a factor of about 100. The PI's have then engaged into an extremely detailed discussion of the key basic questions they felt should be explored before designers could depend on reliable, generic information: 1) the production of arrays of reduced-size microcantilever by sol/gel chemistry and soft lithography, as a way to collect from a given sample, many more simultaneous and real time bio-properties (e.g. in blood). The enhancing effect of silica porosity is expected to be a major one (up to 500 m2/gram). One application of special interest would be, among others, the technology of biosensor microarrays for in vivo situations. 2) the bulk of the remainder of the proposal concerns the state of the art and proposed research departures of the key components of these diagnostics techniques: sensor performance (piezoelectric microcantilevers and nanostructures coatings), ceramics vs. quarts, micromanufacturing, modeling and size effects, biomolecules behavior in nanoporous media.