FASEB Summer Conference on Phospholipases to be held July 9-13, 2000 in Snowmass Village, Colorado

Leslie0075879这笔赠款是对FASEB磷脂酶夏季研究会议的部分支持。 会议旨在回顾磷脂酶A2、C和D的结构、功能和调节的现状。 这些普遍存在的酶通过产生介导多种细胞反应的脂质产物来触发主要的信号转导途径。 磷脂酶A2酶释放花生四烯酸，这是产生类花生酸和血小板活化因子的第一步，类花生酸和血小板活化因子是炎症介质。 磷脂酶C介导聚磷酸肌醇和二酰基甘油的产生，其调节钙水平和蛋白激酶C。 磷脂酶D酶从磷脂酰胆碱产生磷脂酸，并且涉及调节囊泡运输、有丝分裂发生、呼吸爆发氧化酶和其他酶。 这次会议将汇集酶学家和分子细胞生物学家，为深入的科学讨论提供机会。 它还将促进年轻研究人员和资深科学家之间的互动。

Leslie0075879This grant is for partial support for a FASEB Summer Research Conference on Phospholipases. The conference aims to review the current status of what is known about the structure, function and regulation of phospholipases A2, C and D. These ubiquitous enzymes trigger major signal transduction pathways by producing lipid products that mediate diverse cellular responses. Phospholipase A2 enzymes release arachidonic acid, which is the first step in the production of the eicosanoids and platelet activation factor, which are inflammatory mediators. Phospholipase C enzymes mediate the production of polyphosphoinositols and diacylglycerols, which regulate calcium levels and protein kinase C. Phospholipase D enzymes produce phosphatidic acid from phosphatidylcholine and are implicated in regulating vesicle trafficking, mitogenesis, respiratory burst oxidase and other enzymes. This conference will bring together enzymologists and molecular cell biologists to provide an opportunity for in depth scientific discussions. It will also promote interactions between young investigators and senior scientists.