Synthesis of Novel Carbohydrate-Based Materials as Scaffolds for Unique Structural Motifs

本研究的重点是制备NeuAc同聚物和NeuAc/ α -氨基酸偶联物，形成具有独特二级结构的化合物。酰胺连接的低聚物将与生物素结合进行生物筛选，并与可聚合的脂质结合进行蛋白质筛选。低聚物将被共轭形成三级结构或卷曲的线圈。圆二色性和反检测核磁共振技术将用于阐明所得聚氰胺的结构。有机和大分子化学项目用这个更新的奖项来支持亚利桑那大学化学系杰奎琳·格维-黑格博士的研究。Gervay-Hague教授将专注于在水溶液中具有稳定二级结构的新型碳水化合物基材料的合成和表征。这是人造蛋白质工程的第一步。这些材料在药物输送、生物传感器、亲和材料和化学催化剂方面具有潜在的影响。此外，该项目为人力资源开发提供了多样化和多方面的培训环境。

The focus of this research is the preparation of NeuAc homooligomers and NeuAc/alpha-amino acid conjugates to form compounds with unique secondary structures. Amide-linked oligomers will be conjugated with biotin for biological screening and to polymerizable lipids for protein screening. Oligomers will be conjugated to form tertiary structures or coiled coils. Circular dichroism and inverse detected nuclear magnetic resonance techniques will be used to elucidate structure of the resulting polysialoamides.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Jacquelyn Gervay-Hague of the Department of Chemistry at the University of Arizona. Professor Gervay-Hague will focus her work on the synthesis and characterization of new carbohydrate-based materials with stable secondary structures in aqueous solution. This is the first step toward engineering artificial proteins. These materials have potential impact for use in drug delivery, as biosensors, as affinity materials and as chemical catalysts. Further, the project provides a diverse and multidimensional training environment for human resource development.