Surfactant Transition Metal Chelates

有了这个更新奖的有机和高分子化学计划支持博士大卫A。位于拉勒米的怀俄明州大学化学系的耶格说。 建议的研究涉及的合成，分离和表征的两个系列的表面活性剂的基础上钴（III）螯合物，使用相关的配体乙二胺四乙酸和氨三乙酸。 将使用核磁共振光谱（1H、13 C和59 Co的NMR）、UV/维斯、FT-IR和单晶X射线衍射确定表面活性剂的结构。 水中的聚集体形态将通过Krafft温度和临界聚集浓度的测量、NMR、动态光散射、差示扫描量热法、光学显微镜和电子显微镜来表征。 水上的单分子层将通过表面压力-面积等温线来表征。 特别令人感兴趣的是聚集体形态和单分子层行为对表面活性剂立体化学的依赖性。（如空气和水）-其中螯合配体与钴+3离子的结合在固定所得表面活性剂分子的结构中起重要作用，并赋予它们与没有金属结合时不同的性质。 通过系统地改变配体结构，他希望了解控制所得表面活性剂结构和性质的因素。 这类新的分子可能有几个应用，包括氧化还原开关系统，位点特异性蛋白质和DNA裂解催化剂，以及酰胺和酯的催化水解。 这项工作预计将提供有价值的培训学生做的工作，因为涉及的各种实验和仪器。

With this renewal award the Organic and Macromolecular Chemistry Program supports the work of Dr. David A. Jaeger in the Department of Chemistry at the University of Wyoming in Laramie. The proposed research involves the synthesis, isolation, and characterization of two series surfactants based on Co(III) chelates, using ligands related to ethylenediamine tetraacetic acid and nitrilotriacetic acid. The structures of the surfactants will be established using nuclear magnetic resonance spectroscopy (NMR of 1H, 13C and 59Co) , UV/vis, FT-IR, and single crystal x-ray diffraction. Aggregate morphologies in water will be characterized by Krafft temperature and measurements of critical aggregation concentration, NMR, dynamic light scattering, differential scanning calorimetry, optical microscopy, and electron microscopy. Monolayers on water will be characterized by surface pressure-area isotherms. Of particular interest will be the dependence of aggregate morphology and monolayer behavior on surfactant stereochemistry.Dr. Jaeger's research involves surfactants - surface active agents that prefer to be at the interface between phases (such as air and water) - in which binding of chelating ligands to cobalt +3 ions plays an important role in fixing the structure of the resulting surfactant molecule, and in giving different properties from what they would be in the absence of metal binding. By systematically changing the ligand structure, he hopes to understand the factors controlling the structure and properties of the resulting surfactant. This new class of molecules might have several applications including redox-switched systems, site-specific protein and DNA cleavage catalysts, and catalytic hydrolysis of amides and esters. The work is expected to provide valuable training for the students doing the work because of the variety of experiments and instruments involved.