Structure-Reactivity Relationships in Carbanion-Forming Reactions

在有机和大分子化学项目的支持下，加州大学圣克鲁斯分校化学和生物化学系的教授伯纳斯科尼正在探索碳离子形成反应中的结构-活性关系。他的研究重点是费雪型碳络合物的去质子化，这种络合物可以稳定中性碳（通过给电子）和相应的阴离子（通过离域）。给电子和吸电子基团之间复杂的相互作用，导致不寻常的反应模式，正在通过实验和计算方法的结合进行探索。碳离子是带负电荷的分子，在有机化学和有机金属化学中至关重要。它们可以通过许多反应产生，包括，也许是最常见的，从分子中除去一个质子（“去质子化”）。在某些情况下，生成的碳足够稳定，可以对其进行观察，从而测量其性质，从而获得有关反应机制的重要信息。加州大学圣克鲁斯分校化学与生物化学系的Claude F. Bernasconi教授在有机与大分子化学项目的支持下，正在研究这种碳离子形成反应。他的研究涉及化学反应的基本问题以及它们如何受到分子结构的影响，此外，他还为学生提供了广泛的教育经验，从合成和光谱表征到动力学，数据分析和计算化学。

With the support of the Organic and Macromolecular Chemistry Program, Professor Clause F. Bernasconi, of the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, is exploring structure-activity relationships in carbanion forming reactions. His studies focus on the deprotonation of Fischer-type carbene complexes, which offer stabilization of both the neutral carbene (through electron donation) and the corresponding anion (through delocalization). The complex interplay between electron donating and electron withdrawing groups, which leads to unusual reactivity patterns, is being explored through a combination of experimental and computational methods.Carbanions are negatively charged molecules that are of central importance in organic and organometallic chemistry. They can be generated by a number of reactions, including, perhaps most commonly, the removal of a proton from a molecule ("deprotonation"). In some cases, the resulting carbanion is sufficiently stable to allow its observation, permitting the measurement of its properties and thereby yielding important information about reaction mechanisms. Professor Claude F. Bernasconi, of the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, is studying such carbanion forming reactions with the support of the Organic and Macromolecular Chemistry Program. His studies address fundamental questions about chemical reactions and how they are affected by molecular structure, and in addition provide students with a broad educational experience, ranging from synthesis and spectroscopic characterization to kinetics, data analysis, and computational chemistry.