Development of Sensor Coatings Based on Stabilized Planar Lipid Membranes

亚利桑那大学的S. Scott Saavedra教授和他的同事正在开发生物相容性涂层，这种涂层可以作为生物传感设备中蛋白质受体的通用平台。在分析和表面化学计划的支持下，该小组正在研究可聚合平面脂质双分子层的使用。使用Saavedra教授实验室开发的新型光波导光谱方法，评估了特异性和非特异性蛋白质与脂质双分子层的相互作用。生成这些材料的图案微阵列的方法也正在开发中。蛋白质或肽特异性传感器在分析生物系统、监测药物剂量和摄取以及在各种应用中检测生物材料方面显示出巨大的前景。为这些传感器应用开发坚固、通用的基板是本研究项目的主题。利用新型可聚合脂质双分子层，这些生物传感器的通用平台正在开发中。

Professor S. Scott Saavedra and his co-workers at the University of Arizona are developing biocompatible coatings that can be used as a universal platform for the support of protein receptors in biosensing devices. With the support of the Analytical and Surface Chemistry Program, this group is examining the use of polymerizable planar lipid bilayers for this use. Both specific and nonspecific protein interactions with the lipid bilayers are evaluated, using novel optical waveguide spectroscopic methods developed in Professor Saavedra's laboratory. Methods for generating patterned microarrays of these materials are being developed as well. Protein or peptide specific sensors show great promise for analysis of biological systems, for monitoring drug dosages and uptakes, and for detecting biomaterials in a variety of applications. The development of robust, versatile substrates for these sensor applications is the subject of this research project. Using novel polymerizable lipid bilayers, a universal platform for these biosensors is being developed.