Photochemistry with Late Transition Metal Complexes

普渡大学的大卫麦克米兰是由无机，生物无机和有机化学计划的支持，进行后过渡元素和DNA的复合物的光化学研究。 拟议的研究将使用光化学方法来了解后过渡金属卟啉络合物与DNA的结合，并设计指导这种结合的方法。该研究还将开发后过渡系列元素的卟啉和多吡啶络合物，作为具有重要技术用途的新型光敏探针。 许多晚期过渡系列络合物具有开放的配位位置。这种空位所产生的化学灵活性可以被利用来获得对金属物种和DNA之间相互作用的理解。 涉及后过渡金属与DNA的络合物的光化学过程对于产生用于光动力疗法的新药剂以及澄清影响金属物种与DNA结合的因素具有相当大的潜力。

David McMillan of Purdue University is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program to conduct research on photochemistry of complexes of late transition elements and DNA. The proposed research will use photochemical methods to gain understanding of binding of late transition metal porphyrin complexes to DNA and to devise methods to direct that binding. The research will also develop porphyrin and polypyridine complexes of late transition series elements as novel photosensitive probes for technologically important uses. Many late transition series complexes feature open coordination positions. The chemical flexibility engendered by such vacancies can be exploited to gain otherwise unattainable understanding of interactions between metallic species and DNA. Photochemical processes involving complexes of late transition metals with DNA have considerable potential for producing new agents for photodynamic therapy, as well as in clarifying factors influencing the binding of metallic species to DNA.