US-Egypt Cooperative Research: Microsphere Based Tissue Engineering

[015559] Laurencin描述：该奖项是为了支持由化学工程教授Cato Laurencin博士、德雷塞尔大学化学工程系研究助理教授Mohamed Attawia博士和埃及开罗国家研究中心（NRC）陶瓷系Wafaa Ismail博士共同完成的一个合作项目。他们计划开发和研究用于骨组织工程的新型三维基质。这些由德雷塞尔大学开发的基于聚合微球的基质，证明了体外骨附着和生长以及体内矿化中细胞向内生长的能力。NRC的研究人员已经证明了壳聚糖支持成骨细胞和其他间充质细胞的生长和表型表达的能力。近年来对壳聚糖化学改性和壳聚糖络合的研究产生了具有不同物理化学性质的新材料。研究人员计划研究用壳聚糖制备组织工程用微球基质和用可降解高分子材料结合壳聚糖基配合物制备组织工程用微球基质。范围：该奖项将允许在聚合物和生物材料方面具有互补能力和研究经验的美国和埃及科学家之间的合作。这两位美国科学家在他们的领域非常杰出，并且在与该问题相关的领域发表了大量论文。这位埃及合作者是一位活跃的研究人员，在陶瓷、聚合物和生物材料方面拥有技能和专业知识。一名美国学生和一名埃及学生将参与这项研究，并将从国际合作中获得经验。该研究课题是材料科学（特别是生物材料）界和医学界广泛关注的课题。这一建议符合国际原子能机构在互利领域加强国际科学合作的目标。该项目由生物工程与环境系统学部和国际项目学部支持。

0115595LaurencinDescription: This award is for support of a cooperative project by Dr. Cato Laurencin, Professor of Chemical Engineering, and Dr. Mohamed Attawia, Research Assistant Professor, Department of Chemical Engineering, Drexel University, and Dr. Wafaa Ismail, Department of Ceramics at the National Research Center (NRC), in Cairo, Egypt. They plan to develop and study novel three-dimensional matrices useful for tissue engineering of bone. These matrices, developed at Drexel and based on polymeric microspheres, demonstrate the ability to allow for attachment and growth of bone in vitro and cellular ingrowth in mineralization in vivo. Work by researchers at the NRC has demonstrated the ability of chitosan to support the growth and phenotypic expression of osteoblasts and other mesenchymal cells. Recent research for the modifications of chitosan chemistry and chitosan complexation resulted in new materials with ranges of physicochemical properties. The investigators plan to study microsphere based matrices for tissue engineered matrices made from chitosan and microsphere based matrices for tissue engineering using degradable polymeric materials combined with chitosan based complexes. Scope: This award will permit collaboration between US and Egyptian scientists who have complementary capabilities and research experience in polymers and biomaterial. The two US scientists are eminent in their field and are highly published in areas related to the problem. The Egyptian collaborator is an active researcher with skills and expertise in ceramics, polymers, and biomaterials. One US student and one Egyptian student will participate in this research and will gain experience from the international collaboration. The research topic is of broad interest both to the materials science (especially biomaterials) community and to the medical science community. This proposal meets the INT objective of increasing international scientific collaboration in areas of mutual benefit. The project is supported by the Division of Bioengineering and Environmental Systems and the Division of International Programs.