MRI: Acquisition of a Confocal Microscope for Biological Research

已向E博士颁发了一笔赠款。H.彼得森和四个合作PI在俄亥俄州大学为购买激光扫描共聚焦显微镜的生物研究。共聚焦显微镜是现代生命科学研究的重要工具，特别是在分子生物学和神经科学中。有了它，研究人员使用一个或多个激光照射组织，并通过计算机成像来记录和分析结果数据。共聚焦显微镜将配置有四条激光线和专用软件，用于三维图像重建和量化以及生理过程的测量。共聚焦显微镜的费用将由俄亥俄州大学和俄亥俄州董事会分担。 共聚焦显微镜将服务于几个联邦资助的研究项目，包括（a）内耳受体的生物力学，（B）植物细胞壁功能的分子分析，（c）内皮细胞和可用于药物递送的纳米颗粒之间的相互作用，（d）昆虫的生化和生理过程，（e）简单生物系统中的神经网络，（f）转基因番茄和烟草细胞，和（g）癫痫脑组织中的钙动力学。 新的共聚焦显微镜将服务于三个学院和六个学术部门的教师和学生。它提供了一个国家的最先进的成像设施，研究生和本科生的培训在一个传统的服务不足的地区：农村阿巴拉契亚。俄亥俄州大学的主要使命是本科教育，科学和工程系有通过校内项目和联邦赠款指导本科研究的悠久传统。新的共焦显微镜将提供给这些学生通过他们的研究项目与科学和工程学院。此外，它将加强现有的课程和研究培训，为大学的科学和工程研究生。

A grant has been awarded to Dr. E. H. Peterson and four co-PIs at Ohio University for the purchase of a laser scanning confocal microscope for biological research. Confocal microscopy is an essential tool in modern life science research, particularly in molecular biology and neuroscience. With it, the investigator uses one or more lasers to illuminate tissues, and computerized imaging to record and analyze the resulting data. The confocal microscope will be configured with four laser lines and specialized software for three-dimensional image reconstruction and quantification and for measurement of physiological processes. Costs of the confocal microscope will be shared by Ohio University and the Ohio Board of Regents. The confocal microscope will serve several federally funded research programs including (a) biomechanics of receptors in the inner ear, (b) molecular analyses of plant cell wall function, (c) interactions between endothelial cells and nanoparticles that can be used for drug delivery, (d) biochemical and physiological precess in insects, (e) neural networks in simple biological systems, (f) transgenic tomato and tobacco cells, and (g) calcium dynamics in epileptic brain tissues. The new confocal microscope will serve faculty and students in three colleges and six academic departments. It provides a state-of-the-art imaging facility for graduate and undergraduate student training in a traditionally underserved area: rural Appalachia. Ohio University's primary mission is undergraduate education, and the science and engineering departments have a strong tradition of mentoring undergraduate research through intramural programs and federal grants. The new confocal microscope will be available to these students through their research projects with science and engineering faculty. In addition, it will enhance existing course offerings and research training for the university's science and engineering graduate students.