FOR 1363: Biogenic Amines in Insects: Coordination of Physiological Processes and Behaviour

生物胺作为经典的递质，作为神经调质和神经激素，存在于所有动物物种，包括脊椎动物和无脊椎动物，包括人类。生物胺属于递质，在生物进化的早期出现，并在类似的生理环境中重复使用。在人类中，严重的病理，如帕金森或精神病是由生物胺引起的。由于其有利的实验可及性，昆虫允许在不同水平上研究生物胺：（1）就生物胺受体分子及其与细胞内信号传导途径的关联而言，在分子水平上，（2）就释放生物胺及其靶组织或靶神经元的神经元而言，在细胞水平上，（3）就整个神经元网络而言，在系统器官水平上，其受生物胺的影响;（4）就行为过程而言，在行为水平上，生物胺起关键作用。研究单位的目的是弥合不同的水平，从而更全面地了解生物胺的作用。

Biogenic amines act as classical transmitter, as neuromodulators and neurohormones and are found in all animal species, both of vertebrates and invertebrates, including humans. Biogenic amines belong transmitters, which appear early during evolution of organisms and are used repeatedly in similar physiological contexts. In humans severe pathologies such as Parkinson or psychotic disease are caused by biogenic amines. Due to their favourable experimental accessability, insects allow to study biogenic amines at different levels: (1) at a molecular level as far as biogenic amine receptor molecules and their association with intracellular signalling pathways are concerned, (2) at a cellular level as far as the neurons are concerned, which release biogenic amines and their target tissues or target neurons, (3) at a systemic-organismic level as far as whole networks of neurons are concerned, which are influenced by biogenic amines, and (4) at a behavioural level as far as behavioural processes are concerned in which biogenic amines play a key function. The aim of the Research Unit is to bridge the different level and, thus, come to a more complete understanding of biogenic amine action.