Genome sequence of a Streptococcus dysgalactiae subsp. equisimilis, possessing the group A carbohydrate cell wall antigen, and its comparative genomics

欠乳链球菌（Streptococcus dysgalactiae, Sde）是一种人类病原体，可引起从轻度咽炎到严重脓毒症的多种感染，可能包括中毒性休克综合征。这种溶血链球菌显然与另一种更严重的人类病原体化脓性链球菌密切相关，化脓性链球菌携带A族碳水化合物细胞壁抗原（因此也被称为A族链球菌或GAS）。半乳糖失调菌。equissimilis大多具有C组或G组抗原（因此称为GCS或GGS）。这个项目将产生第一个完整的半乳糖不良链球菌亚种基因组。具有A群抗原的等高线虫菌株。获得的基因组数据以及与其他已完成的链球菌基因组的比较基因组研究，特别是来自化脓性链球菌和动物来源的C群和G群链球菌的基因组，将对导致人类疾病的乙型溶血性链球菌的致病性特性产生非常有用的信息。它还将为开发针对乙型溶血链球菌引起的疾病的疫苗提供急需的数据。

Streptococcus dysgalactiae subspecies equisimilis (Sde) is a human pathogen causing a variety of infections from mild pharyngitis to severe sepsis possibly including cases of toxic shock syndrome. This beta-hemolytic Streptococcus species apparently is closely related to another even more serious human pathogen, Streptococcus pyogenes, carrying the group A carbohydrate cell wall antigen (therefore also referred as Group A Streptococcus or GAS). S. dysgalactiae subsp. equisimilis mostly possesses either the group C or the group G antigen (therefore referred to as GCS or GGS). This project will result in the first complete genome of a Streptococcus dysgalactiae subsp. equisimilis strain possessing the group A antigen. The genomic data obtained and a comparative genomic study with other completed streptococcal genomes, especially from S. pyogenes and groups C and G streptococci of animal origin will result in very useful information on the properties essential for the pathogenicity of beta-hemolytic streptococci causing disease in humans. It will also provide highly wanted data for the development of vaccines directed against diseases caused by beta-hemolytic streptococci.