The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity.

膳食硒补充剂作为一系列人类健康状况的预防性治疗具有很大的潜力，包括广泛影响澳大利亚人口的癌症。然而，该等治疗的不利影响并未完全确认。该项目将增加我们对硒化合物如何在体内储存和利用的知识，并将这些信息与有关硒和其他化合物饮食摄入的临床观察联系起来。产生的新认识将描述安全摄入的条件，以便更有效地利用与硒补充相关的有益效果。

Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to clinical observations regarding dietary intake of selenium and other compounds. The new understanding generated will delineate the conditions for safe intake, so that the beneficial effects associated with selenium supplementation may be harnessed more effectively.