U.S.-France Cooperative Research: Optically Pure Ortho-Quinone Methide Complexes- Synthesis and Stereoselective C-C Bond Formation

0128861 Grotjahn这是一个为期三年的美国-法国有机金属化学合作奖，涉及圣地亚哥州立大学和皮埃尔和玛丽居里大学（巴黎六）的研究人员和学生。 道格拉斯B。美国的Grotjahn和法国的哈尼阿穆里领导了对稳定金属络合物的进一步研究--简单的邻醌甲基化物（o-QMs）--最近由阿穆里团队发现。 在没有金属的情况下，o-QMs能够形成复杂的有机分子或破坏DNA。 Amouri-Grotjahn合作将使用金属通过紧密结合来稳定o-QM。初步研究显示o-QM络合物与金属铱的反应性。 其他金属的络合物预期显示不同的反应性。研究人员将使用协调的o-QM配体来创建新的碳-碳键和环。 光学纯的o-QM复合物样品将用于制备产品的单一对映体（镜像）。美国研究人员将利用先进的核磁共振（NMR）技术在光学活性有机分子和有机环加成合成应用方面的专业知识带到了这次合作中。 法国在醌甲基化物配合物化学及其应用方面的专门知识对此予以补充。 该合作促进了对o-QM配合物及其在产品中的合成应用的理解。来自主要本科研究机构的学生将获得国际经验，并受益于法国实验室使用的新合成技术的培训。该奖项代表了美国方面向NSF和CNRS提出的平行建议。 NSF将支付美国研究人员和学生的旅费和生活费。 CNRS将支持法国研究人员和学生访问美国。

0128861GrotjahnThis three-year award for US-France collaboration in organometallic chemistry involves researchers and students at the San Diego State University and University Pierre and Marie Curie (Paris VI). Douglas B. Grotjahn in the US and Hani Amouri in France lead further investigations of stable metal complexes - simple ortho quinone methides (o-QMs) - discovered recently by the Amouri team. In the absence of metal, o-QMs are capable of forming complex organic molecules or damaging DNA. The Amouri-Grotjahn collaboration will use metals to stabilize the o-QM by binding tightly to it. Preliminary studies show reactivity of o-QM complexes with the metal iridium. Complexes of other metals are expected to show different reactivity. The investigators will use coordinated o-QM ligands to create new carbon-carbon bonds and rings. Optically pure samples of o-QM complexes will be used to make single enantiomers (mirror images) of the products.The US investigator brings to this collaboration expertise in optically active organic molecules and synthetic application of organic cycloadditions using advanced Nuclear Magnetic Resonance (NMR) techniques. This is complemented by French expertise in the chemistry of quinone methide complexes and their application. The collaboration advances understanding of o-QM complexes and their synthetic applications in products.Students from a predominantly undergraduate research institution will gain international experience and benefit from training in new synthetic techniques used in the French laboratory.This award represents the US side of parallel proposals to the NSF and the CNRS. NSF will cover travel funds and living expenses for the US investigator and students. The CNRS will support visits by French researchers and students to the United States.