SBIR Phase II: Nanomaterial for Microchip Chemical Sensors

这个小型企业创新研究(SBIR)第二阶段项目将开发一种新型的微芯片化学分析仪，其中包含一种新的纳米材料，可以对少量化学品和生物化学品进行分离和检测。第一阶段通过在玻璃芯片上刻蚀的20×50微米通道中加入一种专利纳米材料，并对几种测试化学品进行化学分离和表面增强拉曼光谱分析，证明了其可行性。第二阶段将通过设计适合集成微流控和拉曼系统的可重复使用的塑料微芯片卡来完成微芯片化学分析仪的开发。发展将包括以下化学品：对氨基苯甲酸、苯乙炔、腺嘌呤、对乙酰氨基酚、仲巴比妥醇、可卡因及其相关代谢物。微芯片分析仪将在农业、生物技术、化学制剂、环境、医疗和制药行业具有广泛的商业价值。具体地说，该微芯片正在设计用于测量体液中的药物和代谢物，以帮助新药的临床试验，辅助化疗药物的剂量控制，并诊断药物过量。

This Small Business Innovation Research (SBIR) Phase II Project will develop a novel microchip chemical analyzer that incorporates a new nanomaterial that performs both separation and detection of small quantities of chemicals and biochemicals. Phase I demonstrated feasibility by incorporating a proprietary nanomaterial in 20- by 50-micron channels etched in a glass microchip and performing chemical separation and surface-enhanced Raman spectral analysis of several test chemicals. Phase II will complete development of the microchip chemical analyzer by designing reproducible plastic microchip cards that fit into an integrated micro-fluidics and Raman system. Development will include the following chemicals: p-aminobenzoic acid, phenyl acetylene, adenine, acetaminophen, secobarbitol, cocaine, and related metabolites.The microchip analyzer will have broad commercial value to the agricultural, biotech, chemical agents, environmental, medical and pharmaceutical industries. Specifically, the microchip is being designed to measure drugs and metabolites in body fluids to aid clinical trials of new drugs, assist dosage control of chemotherapeutic drugs, and diagnose drug overdose.