Upgrade of a High Resolution Mass Spectrometer

在化学研究仪器和设施（CRIF）计划的支持下，位于塔斯卡卢萨的亚拉巴马大学化学系将升级和改造现有的高分辨率质谱仪。这台设备将加强许多领域的研究，包括1）硫，硒和碲化合物的有机化学; 2）四吡咯的生物合成; 3）离子液体在快速原子轰击质谱中的应用; 4）氟化学研究; 5）仿生铬羧酸盐组件的表征;以及6）将修饰的核苷掺入核酸。质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。 它是发展最快、使用最广泛的分析仪器技术之一。 这些研究将在生物化学和合成有机化学等领域产生重大影响。 此外，包括研究生、本科生和当地高中教师在内的50多名学生研究人员将在未来几年内在大学的研究项目中使用质谱仪。 该工具也将提供给其他区域大学的学生和教师。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Alabama in Tuscaloosa will upgrade and refurbish an existing high resolution mass spectrometer. This equipment will enhance research in a number of areas including 1) the organic chemistry of sulfur, selenium, and tellurium compounds; 2) the biosynthesis of tetrapyrroles; 3) applications of ionic liquids for fast atom bombardment mass spectrometery; 4) studies of fluorine chemistry; 5) the characterization of biomimetic chromium carboxylate assemblies; and 6) the incorporation of modified nucleosides into nucleic acids. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. It is one of the fastest growing and most widely used analytical instrumentation techniques. These studies will have a significant impact in a number of areas including biochemistry and synthetic organic chemistry. In addition, over 50 student researchers including graduate students, undergraduate students and local high school teachers will use mass spectrometry in their research projects at the university over the next few years. This instrument will also be available to students and faculty at other regional universities.