Studies of Reactive Intermediates

该项目以高能、短寿命、反应性分子为研究对象。感兴趣的分子是通过合成前体的光解产生的，并鉴定了它们的化学反应的稳定产物。通过在纳秒到皮秒的时间尺度上的紫外-可见光和红外光谱研究，再加上密度泛函理论的计算，将针对四个主要目标。将测量光化学产生的活性中间体向溶剂散热的速率，并将探索当它们冷却时可能发生的向更稳定的异构体的重排。新的反应中间体将通过前驱体在77K下的纳秒时间分辨闪光光解来探索。我们将考察卡宾在配位溶剂中的特定溶剂化作用。卡宾和硝烯与盐反应产生的卡宾和硝烯类化合物将通过时间分辨光谱和化学反应研究进行表征。有了这个奖项，有机和高分子化学计划继续支持俄亥俄州立大学化学系马修·S·普拉茨教授的研究。普拉茨教授创造和研究了有趣的、高活性和短寿命的分子。虽然这种分子具有基本的科学价值，但它们在制造更大的分子方面具有很大的实用价值。它们还被生物化学家用来将小的探针分子连接到较大的分子上，如蛋白质，被材料科学家使用，并在工业上用作光刻胶和光刻。从事这个项目的学生将被教育成为问题解决者，他们最终将把他们的技能应用于解决化学和制药行业以及学术界的问题。

This project targets high energy, short lived, reactive molecules for study. The molecules of interest are generated by photolysis of synthetic precursors and the stable products of their chemical reactions are identified. Through UV-visible and infrared spectroscopic studies at time scales ranging from nanosecond to picosecond, complemented by Density Functional Theory calculations, four main objectives will be targeted. The rates with which photochemically generated reactive intermediates lose heat to solvent will be measured, and possible rearrangements to more stable isomers as they cool will be explored. New reactive intermediates will be probed by nanosecond time resolved flash photolysis of precursors at 77K. Specific solvation of carbenes in coordinating solvents will be examined. Carbenoids and nitrenoids derived from the reactions of carbenes and nitrenes with salts will be characterized by both time resolved spectroscopy and by chemical reactivity studies.With this Award, the Organic and Macromolecular Chemistry Program continues support for the research of Professor Matthew S. Platz of the Department of Chemistry at Ohio State University. Professor Platz creates and studies interesting highly reactive and short-lived molecules. Although such molecules are of basic scientific interest, they have much practical value in making larger molecules. They are also used by biochemists to attach small probe molecules to larger ones such as proteins, by materials scientists and in industry as photoresists and in lithography. Students working on this project will be educated to become problem solvers who will eventually apply their skills to solving problems in the chemical and pharmaceutical industries and in academe.