SBIR Phase I: Development and Manufacture of High-Density Plate Washer

这个小企业创新研究（SBIR）第一阶段项目建议为高密度微孔板（每板1536或更多孔）开发高密度洗板机。目前，有96或384孔板的自动洗板机，大量用于ELISA检测或大多数其他生化或细胞检测。然而，对于超高密度的印版则没有。这是因为目前可用的清洗机技术还不够可靠，不能保证分送和抽吸喷嘴始终到达每口非常小的井中，也不能保证所需的许多细喷嘴不会堵塞。该项目将采用全新的设计来解决这些问题。这项拟议中的技术将使科学家能够清洗1536个孔板。这意味着荧光化合物现在可以用于筛选，因为它们在测量样品之前被去除。这将意味着学术和商业科学家在筛选过程中节省成本和效率。该项目的商业应用将是一种新产品，可用于参与药物发现筛选项目的研究团体。

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a high-density plate washer for very high-density microplates (1536 or more wells per plate). Currently, there are automated plate washers for 96 or 384 well plates that are heavily used for ELISA assays or most other biochemical or cell-based assays. However, there are none for plates with ultra-high density. This is because currently available washer technology cannot be made reliable enough so that dispense and aspirate nozzles consistently reach within each of the many, very small wells, and so that the many thin nozzles needed do not clog. This project will incorporate a wholly innovative design to get around these problems. The proposed technology will allow scientists to wash the 1536 well plates. The implications are that fluoroscent chemical compounds can now be used for screening because they are removed before the measurement of the samples. This will mean cost savings and efficiency in the screening process for both academic and commercial scientists.The commercial application of this project will be a new product that can be used by the research community involved in screening programs for drug discovery.