Development of Novel s-Block Organometallic Reagents

该研究计划将建立一系列第2族有机金属化合物作为试剂的广泛实用性，以进行各种重要的合成有机转化。镁双酰胺将被开发为对映选择性去质子化反应的选择性碱。镁试剂将探索的效果不对称诱导加成反应烯醇阴离子和跨羰基，在对映选择性还原，和不对称Wittig型反应。还将研究同手性重族2类似物（Ca、Ba、Sr）的相关化学。反应性研究将与结构和理论分析相辅相成。有了这个新的奖项，有机和大分子化学计划是支持教授肯尼思W。圣母大学化学和生物化学系的亨德森说。亨德森教授正在探索合成，结构和反应性的不寻常的化合物含有镁，钙，钡，锶。这些化合物提供了实现高选择性有机化学转化的希望，同时提供了许多优于更传统试剂的实际优点，包括低毒性、低成本和有效功能，而不需要特殊的反应条件。

This research program will establish the broad-based utility of a series of group 2 organometallic compounds as reagents to perform a variety of synthetically important organic transformations. Magnesium bisamides will be developed as selective bases for enantioselective deprotonation reactions. Magnesium reagents will be explored which effect asymmetric induction in addition reactions to enolate anions and across carbonyls, in enantioselective reductions, and in asymmetric Wittig-type reactions. The related chemistry of homochiral heavier group 2 analogs (Ca, Ba, Sr) will also be studied. Reactivity studies will be complemented with structural and theoretical analyses.With this new award, the Organic and Macomolecular Chemistry Program is supporting the work of Professor Kenneth W. Henderson, of the Department of Chemistry and Biochemistry at the University of Notre Dame. Professor Henderson is exploring the synthesis, structure, and reactivity of unusual compounds containing magnesium, calcium, barium, and strontium. These compounds offer promise for effecting highly selective organic chemical transformations while providing a number of practical advantages over more traditional reagents, including low toxicity, low cost, and effective function without the need for specialzied reaction conditions.