Structure-Reactivity Relationships in Carbanion Chemistry

通过这项更新提案，有机和高分子化学项目继续支持纽约州伊萨卡市康奈尔大学化学系大卫·B·科勒姆教授的工作。这项研究将扩展PI在结构-反应性关系以及它们与有机锂化学中重要合成反应的相关性方面的工作。研究将集中在四个主要的反应：1，2加成，邻位石化，Fries重排和苯并生成。将结合核磁共振波谱研究、动力学测量和计算化学来探索在这些重要反应中溶剂化、聚集和反应性之间的相互作用。这些拟议的研究有望为合成化学家提供许多有价值的信息，并允许将金金属化学扩展到新的应用领域。由于本项目中将研究的许多试剂也用于制备一些最重要的药物，这些研究在基础学术研究和应用工业研究之间提供了一个独特的接口。在这一供资期间，将继续与制药实验室在诸如制备抗成瘾药物等领域进行合作。这项工作将为学生在一个连接学术和工业化学的重要领域提供有价值的专业准备。

With this renewal proposal the Organic and Macromolecular Chemistry Program continues its support for the work of Professor David B. Collum of the Department of Chemistry at Cornell University in Ithaca, NY. The research will extend the PI's work on structure-reactivity relationships and their correlation with important synthetic reactions in organolithium chemistry. The research will focus on four major reactions: 1,2 additions, ortholithiations, Fries rearrangements, and benzyne formation. A combination of NMR spectroscopic investigations, kinetic measurements, and computational chemistry will be used to probe the interplay between solvation, aggregation, and reactivity in these important reactions. The proposed investigations are expected to provide synthetic chemists with much valuable information and allow extensions of ogranometallic chemistry into new applications.Since many of the reagents to be investigated in this project are also used to prepare some of the most pharmaceutically important drugs, these studies offer a unique interface between basic academic and applied industrial research. Collaborations with pharmaceutical laboratories, in areas such as the preparation of anti-addiction drugs, will continue during this funding period. This work will provide valuable professional preparation for students in an important field that bridges academic and industrial chemistry.