FIBR Planning: Genome Dynamics and Evolutionary Processes in a Dioecious System

智力优势-常染色体上的基因，性染色体上的基因，线粒体和叶绿体中的基因，以及那些与转座因子相关的基因，通过不同的途径和不同的规则遗传。然而，这些元素在单个个体中的出现，其表型受到它们的影响，产生了复杂的进化过程，影响了染色体进化和基因组重组等现象。 这项计划赠款的目标是开发被子植物属Silene及其相关病原体Microbotryum，作为了解有性生殖系统进化和遗传学的模型系统。 蝇子草-微孢菌群落已经成功地将这些物种发展成为研究性别决定和宿主-病原体系统的模式系统。 该FIBR计划项目的目标是围绕开发一套共同的基因组资源组织该社区，整合该领域的现有工作人员，并减少开发共同资源的重复工作。 为了实现这一目标，将举行一次研究研讨会，不仅包括研究这一系统的科学家，还包括一组基因组学、分子生物学和理论生物学方面的专家，他们分享概念上的兴趣，但与其他生物体一起工作。 随后，将举行一个FIBR PI研讨会，以制定提案本身。 这个项目是集中在这个系统的优势，在回答问题，是不容易接近其他模型系统。 这些优势包括密切相关的类群内的广泛系统，病原体动力学及其与生殖系统相互作用的深入知识，以及对所考虑的进化过程的生态和地理环境的深刻理解。更广泛的影响-这项规划活动将吸引代表广泛的机构类型和地理上分散的研究人员。 研究研讨会强调学生和博士后的直接参与，并建立在主要研究人员正在进行的外联工作的基础上。 专题讨论会和规划会议将提供机会，制定进一步的计划，以加强教育和外联机会，作为预期的预先提案的一部分。 更一般地说，规划生物多样性研究国际联合会的预提案将包括促进人口动态和分子方法相结合的机制，并通过跨学科和强调广泛和比较的方法帮助青年科学家的职业发展。

Intellectual Merit - Genes on autosomes, on sex-chromosomes, in mitochondria and chloroplasts, and those associated with transposable elements are inherited through different pathways and with different rules. Yet the occurrence of these elements within single individuals, whose phenotype they influence, creates complex evolutionary processes that influence phenomena such as chromosome evolution and genome restructuring. This planning grant has the goal of developing the angiosperm genus Silene and its associated pathogen Microbotryum as model systems for understanding the evolution and genetics of sexual reproductive systems. The Silene - Microbotryum community has successfully developed these species into model systems for the study of sex-determination and host-pathogen systems. The objective of this FIBR planning project is to organize this community around the development of a common set of genomic resources, to integrate the current workers in the field, and to reduce the duplication of effort in developing common resources. A research symposium will be held to achieve this goal and will include not only the scientists working on this system, but also a set of experts in genomics, molecular biology, and theoretical biology who share conceptual interests but work with other organisms. Subsequently, a workshop of the FIBR PIs will be held to develop the proposal itself. This project is centered on the strengths of this system with regard to answering questions that are not readily approachable in other model systems. These strengths include a broad range of systems within closely related taxa, intense knowledge of pathogen dynamics and its interaction with the reproductive system, and a profound understanding of the ecological and phylogeographic context of the evolutionary processes under consideration.Broader Impact - This planning activity will draw together a diverse range of researchers representing a breadth of institutional types and a geographically disperse set. The research symposium emphasizes direct student and post-doctoral participation and builds on the ongoing outreach efforts of the principal investigators. The symposium and planning meetings will provide opportunities to develop further plans for enhancing educational and outreach opportunities as part of the anticipated pre-proposal. More generally, planning for the FIBR pre-proposal will include mechanisms to promote the integration of population dynamic and molecular approaches and help the career development of young scientists by crossing disciplines and emphasizing a broad and comparative approach.