Mechanisms of Transition Metal Catalyzed Reactions in Hydrocarbons

本研究的重点涉及三个方面。首先，将使用三种方法来了解烷基化钌催化剂的失活模式：将确定分解速率作为条件，添加剂和配体结构的函数。分解产物将使用晶体结构和同位素标记进行研究。将制备各种新的1,3-二取代-4,5-二氢咪唑-2-基吡啶及其相关体系，旨在抑制分解途径。其次，将发展纳米级共轭材料层的制备方法和利用嵌段聚合物技术合成多层材料的方法。第三，开发环状聚合物的制备方法，合成各种互锁聚合物拓扑结构。有了这个奖项，有机和大分子化学项目和聚合物项目支持加州理工学院化学和化学工程系Robert H. Grubbs博士的研究。Grubbs教授将把他的工作重点放在开发一系列基于钌的分解催化剂上，这些催化剂在基本层面上具有明确的参数，并且具有高效率和选择性。此外，将探索生产各种具有非常窄分散度的纳米级材料，特别是含有无机结构的材料所需的基本原理。针对环状聚合物的制备和表征的研究也将进行。该项目为培养学生提供了一个极好的场所，并对制药工业和材料科学产生了重要的广泛影响。

The foci of this research involve three areas. First, three methods will be used to understand the modes of deactivation of ruthenium alkylidene catalysts: Rates of the decomposition as a function of condition, additives and ligand structure will be determined. The products of decomposition will be investigated using crystal structures and isotopic labeling. A variety of new 1,3-disubstituted-4,5-dihydroimidazol-2-ylidene and related systems, designed to inhibit decomposition pathways, will be prepared. Second, methods for the preparation of nanoscale layers of conjugated materials and the synthesis of multilayer materials using block polymer techniques will be developed. Third, methods for the preparation of cyclic polymers will be developed and a variety of interlock polymer topologies will be synthesized.With this award, the Organic and Macromolecular Chemistry Program and the Polymers Program are supporting the research of Dr. Robert H. Grubbs in the Department of Chemistry and Chemical Engineering at the California Institute of Technology. Professor Grubbs will focus his work on developing a family of ruthenium based metathesis catalysts that have well defined parameters at the fundamental level and that are highly efficient as well as selective. Further, the fundamental principles required to produce a variety of nanoscaled materials with very narrow dispersities, especially materials containing inorganic structures will be explored. Research aimed at the preparation and characterization of cyclic polymers will also be carried out. The project presents an excellent venue for the training of students and has important broader impacts for the pharmaceutical industry and materials science.