Biophotonics: In-Vivo Femtosecond Laser Micro-Surgery Combined with Two-Photon Imaging using Optical MEMS Components

0423732 SolgaardThis提案描述了一项研究计划，将探索新的光子学和纳米技术方法的前沿，以开发一类新的微型探针，用于生物医学成像和体内显微手术。该提案的目标是（1）研究飞秒激光显微手术在组织深处进行的基本原理，（2）探索使用新型空气引导光子带隙光纤传输脉冲能量高达1-uJ的飞秒激光脉冲，（3）开发基于微机电系统（MEMS）技术的微型扫描仪，（4）开发基于MEMS的光谱相位调制器结合无源薄膜涂层技术以补偿脉冲展宽，以及（5）将这些组件集成到宏观显微外科系统中并在体外评估它们的性能。

0423732SolgaardThis proposal describes a research program that will explore the frontiers of novel photonics and nanotechnology methods to develop a new class of miniaturized probes for biomedical imaging and microsurgery in-vivo. The objectives of this proposal are (1) to study the fundamentals of femtosecond laser microsurgery performed deep in tissue, (2) to explore the delivery of femtosecond laser pulses with pulse energies up to 1-uJ using a new class of airguiding photonic band-gap fibers, (3) to develop miniature scanners based on Micro-Electro-Mechanical Systems (MEMS) technology, (4) to develop MEMS based spectral phase modulator in combination with a passive thin film coating technique to compensate for pulse broadening, and (5) to integrate these components into a macroscopic microsurgery system and evaluate their performance in-vitro.