SST: Patchy Sensor Surfaces for Selective Dynamic Adhesion of Micron and SubMicron Objects

摘要提案号：cts -0428455首席研究员：Maria M. SantoreInstitution: University of Massachusetts amherst题目：用于微米和亚微米物体选择性动态粘附的斑块传感器表面该项目将为50纳米至5微米的颗粒开发强大的现场就绪传感器，适用于检测水中和空气环境中的细菌、孢子、病毒、无机细颗粒和化学敏感清除颗粒。专注于可逆的动态粘附，因为这些物体流过检测器表面，在检测事件后自发恢复。在美国，该项目的目标是一种新的传感概念，它将根据生物细胞或无机颗粒的表面来筛选和区分它们的类别。这种类水平的选择性不需要分解细胞、提取蛋白质或遗传物质或进行分子识别的步骤。因此，针对多个应用程序。这种新型传感技术的核心是一种不均匀的或有图案的表面，它对pH值、温度和其他环境因素都有很强的抵抗力，它可以选择性地附着目标颗粒，同时在尺寸或表面特征（表面电荷的平均密度或纳米级分布、纳米级疏水和亲水性化学斑块、粗糙度的尺度和表面形貌的其他方面）上拒绝目标范围以外的颗粒。甚至是特定的肽序列)。传感器表面呈现不同尺寸和化学性质的纳米尺度斑块，以及微米尺度的水动力特征，这些特征产生了一个相互竞争的胶体和水动力景观，以区分接近的胶体颗粒，基于它们的动态特征，包括可逆粘附、滚动、跳跃和停滞。Santore、Coughlin和Davis提议的合作涵盖了聚合物界面、合成化学和流体力学等学科。通过结合实验和建模，团队将开发集热器表面图案的设计规则，稳健的探测器化学，以及操纵浓度，离子强度和流速的操作策略。通过捕获孢子、细菌、病毒、树脂和矿物质的基本特征的模型粒子，该程序将探测图案收集器表面的粘附和脱离率，以及表面特征的尺度和化学的系统变化。表面特征的设计将考虑到特定的胶体力（静电、范德华、疏水和聚合物机械）和水动力场，利用嵌段共聚物结构的多功能性，以及设计用于操纵颗粒表面接触的流场。更广泛的影响。新的传感技术不仅在国土安全方面有益于社会，而且在公共福利方面也有益于社会：传感原理采用的活动表面可以以适中的成本生产，设计可以无人值勤和自动操作，适用于化学过程和公共建筑，如医院和学校，并最终适用于家庭。该计划植根于纳米化学和胶体科学的跨学科领域，影响了聚合物表面化学、生物物理学和模式识别领域，并将启动单细胞生物的表面指纹数据库。研究生将继承大部分基础科学，而联络项目将通过工业/大学混合研究经验使工程、化学和物理本科生受益。本科生将花一个夏天的时间在一个与Santore / Davis/ Coughlin实验室平行的科学项目上，并在学年期间返回麻省理工学院进行相关的研究项目。整合的教学和研究将通过智能接口专题课程和麻省理工大学两个学院的重点本科课程的客座讲座来完成。该项目将针对代表性不足的群体，从当地大学招收在麻省理工学院上课的学生。

AbstractProposal Number: CTS-0428455Principal Investigator: Maria M. SantoreInstitution: University of Massachusetts AmherstTitle: Patchy Sensor Surfaces for Selective Dynamic Adhesion of Micron and Submicron Objects Merit: This program will develop the science for robust field-ready sensors for particles with sizes from 50 nm to 5 um, applicable to the detection of bacteria, spores, viruses, inorganic fines, and chemically-sensitive scavenging particles from aqueous and airborne environments. Focusing on reversible dynamic adhesion as these objects flow over detector surfaces that spontaneously recover after a .detection event., the program targets a new sensing concept that will screen and discriminate classes of biological cells or inorganic particles based on their surfaces. This class-level selectivity will not require steps that lyze cells, extract proteins or genetic material, or conduct molecular recognition. Multiple applications are therefore targeted. At the heart of this new sensing technology lies a heterogeneous or patterned surface which is robust to pH, temperature, and other environmental factors, and which selectively adheres target particles while rejecting those outside target ranges in size or surface character (mean density or nanoscale distribution of surface charge, nano-meter scale patches of hydrophobic and hydrophilic chemistries, scale of roughness and other aspects of surface topography, and even specific peptide sequences). The sensor surfaces present nanometer-scale patches of different sizes and chemistries, and micron-scale hydrodynamic features that generate a landscape of competing colloidal and hydrodynamic forces to discriminate approaching colloidal particles based on their dynamic signature, including reversible adhesion, rolling, skipping, and arrest. The proposed collaboration between Santore, Coughlin, and Davis spans the disciplines of polymer interfaces, synthetic chemistry, and fluid mechanics. Through combined experiment and modeling, the team will develop design rules for collector surface patterns, robust detector chemistry, and operating strategies that manipulate concentration, ionic strength, and flow rates. With model particles capturing the essential features of spores, bacteria, viruses, resins, and minerals, the program will probe adhesion and detachment rates on patterned collector surfaces with systematic variations in the scale and chemistry of surface features. Surface features will be designed with particular colloidal forces (electrostatic, Van der Waals, hydrophobic, and polymer mechanical) and hydrodynamic fields in mind, exploiting the versatility of block copolymer architectures, and flow fields engineered to manipulate particle-surface encounters. Broader impacts. The new sensing technology will benefit society not only in terms of homeland security, but also in terms of public welfare: The sensing principles employ active surfaces which could be produced at modest cost, and designs which can operate unattended and automatically, in chemical processes and public buildings such as hospitals and schools, and ultimately the home. The program, while rooted in the interdisciplinary fields of nanochemistry and colloid science, impacts the fields of polymer surface chemistry, biophysics, and pattern recognition, and will initiate a surface fingerprinting database of single cell organisms. Graduate students will carry forward the bulk of the fundamental science while a liaison program will benefit engineering, chemistry, and physics undergraduates via a hybrid industrial / university research experience. Undergraduates will spend a summer in industry on a project with science parallel to that in the Santore / Davis/ and Coughlin labs, returning to UMass to conduct a related research project during the academic year. Integrated teaching and research will be accomplished with a special topics course on smart interfaces, and with guest lectures in key courses in the undergraduate curriculum of two UMass colleges. The program will target underrepresented groups by recruiting students from local colleges who take courses at UMass.