Exploiting the Hydrodynamic Coupling Effect for Capture and Manipulation of Nanotextured Particles and Cells

利用流体动力耦合效应捕获和操纵纳米结构颗粒和细胞

基本信息

  • 批准号:
    1264855
  • 负责人:
  • 金额:
    $ 38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-08-01 至 2017-07-31
  • 项目状态:
    已结题

项目摘要

The role of surface heterogeneity can play a major role in particle adhesion to surfaces, even when both particle and surface are uniformly charged with the same sign of charge--which should make both surfaces strongly repulsive. The PI has previously demonstrated the magnitude of heterogeneity effect by using heterogeneous collecting surfaces to capture ?homogenous? particles with great specificity and efficiency. This proposal turns its focus on the dynamic consequences of heterogeneity (heterogeneity-driven fluctuations of flowing particles), when heterogeneity resides on the flowing particle rather than the collector. The proposed work will contribute to a broadening of sensing and separations technologies beyond reliance on the bio-molecular recognition paradigm to enable creation of separations and sensing systems that can withstand a broad range of operating conditions. The PI will demonstrate how the fundamental understanding derived from their studies can be translated to 3 specific applications: heterogeneous drug carriers in blood, on-line bacterial sensing, and a non-immuno-based whole-cell cancer diagnostic.
表面非均质性在粒子与表面的粘附中起着重要作用,即使粒子和表面都均匀地带着相同的电荷符号——这应该使两个表面都具有很强的斥力。PI先前通过使用非均质收集表面来捕获非均质?颗粒具有很强的特异性和效率。当非均质性存在于流动的颗粒上而不是收集器上时,该建议将其重点转向非均质性(流动颗粒的非均质性驱动波动)的动态后果。拟议的工作将有助于扩大传感和分离技术的范围,超越对生物分子识别范式的依赖,从而能够创建能够承受广泛操作条件的分离和传感系统。PI将演示如何从他们的研究中获得的基本理解可以转化为3个特定应用:血液中的异质药物载体,在线细菌传感和非基于免疫的全细胞癌症诊断。

项目成果

期刊论文数量(0)
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Maria Santore其他文献

Depletion forces drive surface capture and alter growing cell arrangements of living bacteria
  • DOI:
    10.1016/j.bpj.2023.11.1015
  • 发表时间:
    2024-02-08
  • 期刊:
  • 影响因子:
  • 作者:
    Wuqi Amy Niu;Sloan Siegrist;Maria Santore
  • 通讯作者:
    Maria Santore

Maria Santore的其他文献

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{{ truncateString('Maria Santore', 18)}}的其他基金

Convergence: RAISE Dynamic Touch-based Bacteria-Device Two-Way Communication
融合:RAISE动态触摸细菌-设备双向通信
  • 批准号:
    1848065
  • 财政年份:
    2018
  • 资助金额:
    $ 38万
  • 项目类别:
    Standard Grant
2016 Colloidal, Macromolecular, and Polyelectrolyte Solutions GRC/GRS: Non-Equilibrium and Bio-Inspired Systems, February 6-12, 2016, Ventura, CA
2016 胶体、高分子和聚电解质解决方案 GRC/GRS:非平衡和仿生系统,2016 年 2 月 6-12 日,加利福尼亚州文图拉
  • 批准号:
    1557851
  • 财政年份:
    2016
  • 资助金额:
    $ 38万
  • 项目类别:
    Standard Grant
Micropatterned and NanoTextured Surfaces: From Self-Cleaning to Selective Particle Direction
微图案和纳米纹理表面:从自清洁到选择性颗粒方向
  • 批准号:
    0932719
  • 财政年份:
    2009
  • 资助金额:
    $ 38万
  • 项目类别:
    Standard Grant
Surfaces that Selectively Manipulate and Kill Bacteria
选择性操纵和杀死细菌的表面
  • 批准号:
    0805061
  • 财政年份:
    2008
  • 资助金额:
    $ 38万
  • 项目类别:
    Continuing Grant
SST: Patchy Sensor Surfaces for Selective Dynamic Adhesion of Micron and SubMicron Objects
SST:用于微米和亚微米物体选择性动态粘附的片状传感器表面
  • 批准号:
    0428455
  • 财政年份:
    2004
  • 资助金额:
    $ 38万
  • 项目类别:
    Continuing Grant
GOALI: "Dynamically Responsive Polymeric Additives for Process Improvements an Environmental Compability"
目标:“用于工艺改进和环境兼容性的动态响应聚合物添加剂”
  • 批准号:
    0234166
  • 财政年份:
    2002
  • 资助金额:
    $ 38万
  • 项目类别:
    Continuing Grant
An Immuno-Mimetic Sensor-Actuator using Novel Polymeric Vesicles as Artificial Lymphocytes
使用新型聚合物囊泡作为人工淋巴细胞的免疫模拟传感器致动器
  • 批准号:
    0242647
  • 财政年份:
    2002
  • 资助金额:
    $ 38万
  • 项目类别:
    Continuing Grant
An Immuno-Mimetic Sensor-Actuator using Novel Polymeric Vesicles as Artificial Lymphocytes
使用新型聚合物囊泡作为人工淋巴细胞的免疫模拟传感器致动器
  • 批准号:
    0097676
  • 财政年份:
    2001
  • 资助金额:
    $ 38万
  • 项目类别:
    Continuing Grant
GOALI: "Dynamically Responsive Polymeric Additives for Process Improvements an Environmental Compability"
目标:“用于工艺改进和环境兼容性的动态响应聚合物添加剂”
  • 批准号:
    9817048
  • 财政年份:
    1999
  • 资助金额:
    $ 38万
  • 项目类别:
    Continuing Grant
POWRE: Polysomes: Biologically-Inspired Vesicles of Block Copolymers for Targeted Delivery and Controlled Release Applications
POWRE:多聚体:用于靶向递送和控释应用的嵌段共聚物的生物启发囊泡
  • 批准号:
    9973524
  • 财政年份:
    1999
  • 资助金额:
    $ 38万
  • 项目类别:
    Standard Grant

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