Transition Metal-Mediated Syntheses of Novel Molecules

这项研究的重点是制备苯类化合物，这种化合物由于稠合的环丁二烯与苯环的位置交替而具有独特的电子性质。此外，新的烯烃和炔烃底物将经历钴介导的[2+2+2]环加成反应，包括炔基硼烷和杂芳烃体系。为了测试这种方法的有效性，具有挑战性的天然产物吗啡和螺杆菌亚胺的核心，这两个具有已知或潜在生理活性的系统都将被作为全合成的目标。有了这个续展奖，有机和高分子化学计划将支持加州大学伯克利分校化学系Peter C.Vollhardt博士的研究和教育活动。沃尔哈特教授将把工作重点放在开发构建新型芳香族分子的方法上。该项目将生产一类称为苯系物的新型共轭苯基碳氢化合物，并将重点开发合成天然产物的方法学。在培养本科生、研究生和博士后方面，更广泛的影响很大。

The focus of this research is to prepare phenylenes, compounds that have unique electronic properties due to the position of fused cyclobutadienes alternate with benzene rings. Also, new alkene and alkyne substrates will be subjected to cobalt-mediated [2+2+2] cycloadditions, including alkynylboranes and heteroaromatics systems. To test the validity of the approach, the challenging natural product morphine and the core of aspidospermidine, both systems having known or potential physiological activity will be targeted for total synthesisWith this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Peter C. Vollhardt in the Department of Chemistry at the University of California, Berkeley. Professor Vollhardt will focus his work on developing methods for the construction of novel aromatic molecules. The project will produce a new class of conjugated benzenoid hydrocarbons termed the phenylenes and will focus on the development of methodology for the synthesis of natural products. Broader impacts are strong in the area of training undergraduates, graduate students and postdoctorals.