Regulation and function of actin nucleation in the early Drosophila embryo

在果蝇的早期胚胎中，肌动蛋白丝动态地组织成离散的结构，这些结构由肌动蛋白成核剂复合物控制。鉴于胚胎的快速发育和实验易处理性，有可能将结构和功能联系起来，并在可见的形态发生过程中测试肌动蛋白结构的功能，如膜内陷，核定位，细胞形状和细胞重排。在这里，我们调查的功能和调节的肌动蛋白成核剂透明的质膜组织细胞化和胚带延伸在早期胚胎发育的果蝇。具体来说，我们研究了透明是如何参与定义和维持不同的膜结构域。

In the early embryo of Drosophila, actin filaments are dynamically organised in discrete structures that are controlled by actin nucleator complexes. Given the fast development and the experimental tractablility of the embryos, it is possible to correlate structure and function and test the function of actin structures in visible morphogenetic processes, such as membrane invagination, nuclear positioning, cell shapes and cell rearrangement. Here we investigate the function and regulation of the actin nucleator Diaphanous in plasma membrane organisation during cellularisation and germband extention during early embryonic development of Drosophila. Specifically, we investigate how Diaphanous is involved in defining and maintaining distinct membrane domains.