Collaborative Research: Aortic Aneurysm Pathobiology

摘要本项目拟对腹主动脉瘤（AAAs）的病理行为进行详细的研究。研究人员计划从患者的CT扫描中构建单独的AAAs幻象，并使用这些幻象来分析和表征在稳定和脉动条件下通过幻象的流动模式。在该项目的下一阶段，动脉内皮细胞将被播种到幽灵的内壁，并允许其繁殖。然后在项目早期确定的特定流程和压力测试下测试这些幻影。最后，对细胞进行检测，以确定影响动脉壁弹性和破裂可能性的某些标记物。该项目提供了工程技术、分子生物学和医学的平衡整合。

Kaplan 0502486ABSTRACTThis project proposes a detailed investigation of the pathobiologic behavior of abdominal aortic aneurysms (AAAs). The investigators plan to construct individual phantoms of AAAs from CT scans of patients, and use the phantoms to analyze and characterize the flow patterns through the phantoms under both steady and pulsatile conditions. In the next phase of the project, arterial endothelial cells will be seeded on to the interior wall of the phantoms and allowed to multiply. Then the phantoms are tested under the specific flow and stress tests as determined earlier in the project. Finally, the cells are tested for certain selected markers which affect the arterial wall elasticity and the possibility of rupture. The project offers a balanced integration of engineering techniques, molecular biology and medicine.