Fine Tuning Photochemical Reactions Through Confinement and Cation-Organic Interactions

PI寻求继续他的工作，在使用沸石，以帮助影响非对映选择性和对映选择性的光化学反应。 PI提出沸石笼中的阳离子与光反应性分子和手性助剂一起沿着存在，对不对称光反应的成功或失败至关重要。 存在的阳离子、存在的水合氢离子浓度和存在的手性诱导剂或助剂将系统地变化。 项目期间的主要目标是利用这些信息开发一个模型，以帮助预测和规划沸石内的对映选择性光反应。 有了这个奖项，有机和高分子化学计划正在支持杜兰大学化学系的V. Ramamurthy博士的研究。 Ramamurthy博士将致力于使用沸石促进不对称光化学反应。 待研究的光化学反应产生手性分子（具有两个不可重叠的镜像），并且仅产生两种可能形式中的一种（单一对映体）。 这类反应的发展是当今制药工业面临的最重要的问题之一。 当开发完成后，Ramamurthy博士的工作可以应用于许多生物活性分子的合成。 在这项工作的过程中培训的学生将获得制药行业所需的技能，现在生产一些单一的对映体化合物。

The PI seeks to continue his work in the use of zeolites to help effect diastereoselective and enantioselective photochemical reactions. The PI proposes that the cations which are present in the zeolite cage, along with the photoreactive molecule and chiral auxiliary, are critical to the success or failure of the asymmetric photoreactions. Cations present, hydronium ion concentrations present, and chiral inductors or auxiliaries present will be systematically varied. The main goal of the project period is to use this information to develop a model to help one predict and plan enantioselective photoreactions within zeolites. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. V. Ramamurthy of the Department of Chemistry at Tulane University. Dr. Ramamurthy will work on using zeolites to facilitate asymmetric photochemical reactions. The photochemical reactions to be studied produce molecules which are chiral (have two nonsuperimposable mirror images) and make only one of the two possible forms (a single enantiomer). Development of this family of reactions is one of the most important problems facing the pharmaceutical industry today. When developed, Dr. Ramamurthy's work could be applied to the syntheses of a number of biologically active molecules. Students trained during the course of this work will gain skills needed by the pharmaceutical industry which now produces a number of single enantiomer compounds.