CAREER: Next-Generation Research and Education in Therapeutic Optimization

该学院的早期职业发展（CAREER）研究涉及下一代治疗优化，其中包括构建疾病进展的定量模型，并优化特定的一组疗法。这项建议的智力价值集中在终末期肝病的三个广泛领域，这是美国的主要杀手之一，但这项研究也适用于其他疾病。第一个广泛的领域解决了在传统的运筹学应用中不常见的治疗优化中出现的问题，并描述了解决其中三个问题的方法。第二个广泛的领域描述了如何考虑病人的观点模型可以用来解决政策问题。第三个广泛的领域，也许是最雄心勃勃的，考虑整合患者和社会观点的肝脏分配机制。拟议工作的更广泛影响将直接由数千名终末期肝病患者感受到，并通过治疗优化领域的显着改进间接由数百万人感受到。该教育计划将直接影响四个群体：医学研究人员，主要是医学博士;博士生谁应用最先进的运筹学技术，以复杂和现实的医疗问题;本科生和研究人员;和高中生。研究和教育计划是很好地结合在一起的，一个方面的进展将有助于另一个方面。

This Faculty Early Career Development (CAREER) research addresses next-generation therapeutic optimization, which involves constructing quantitative models of disease progression, and optimizing a particular set of therapies. The intellectual merit of this proposal focuses on three broad areas in end-stage liver disease, one of the leading killers in the United States, but the research applies to other diseases as well. The first broad area addresses issues that arise in therapeutic optimization that are uncommon in traditional operations research applications, and describes methods to address three of these. The second broad area describes how models that consider the patient's perspective can be used to address policy questions. The third broad area, perhaps the most ambitious, considers liver allocation mechanisms that integrate the patient's and societal perspectives. The broader impacts of the proposed work will be felt directly by thousands of end-stage liver disease patients, and indirectly by millions more through significant improvements in the field of therapeutic optimization. The educational plan will directly impact four groups: medical researchers, primarily MDs; PhD students who apply state-of-the-art operations research techniques to complex and realistic medical problems; undergraduate students and researchers; and high school students. The research and educational plans are well integrated, and progress in one will aid the other.