CAREER: Fluorescent, Biofunctionalized Conjugated Polymer Nanoparticles for Advanced Labeling and Sensing Applications

克莱姆森大学的Jason McNeill教授得到了分析和表面化学计划的支持，开发用于生物检测和成像的新型荧光纳米颗粒。其战略是开发具有高荧光聚合物核和壳的核-壳纳米颗粒传感器，该壳将为蛋白质、抗体和DNA等生物分子的附着提供表面。传感器将使用先进的光谱和显微技术进行测试。先进的应用，如监测细胞内的分子相互作用，也将被研究。教育计划详细说明了将这项研究纳入研究生和本科生教育和培训的综合计划。该项目将向公众传播有关纳米材料、纳米科学和工程的信息。许多疾病和病原体检测涉及使用基于荧光的检测方案。该项目将产生比传统荧光染料更明亮的基于聚合物的荧光纳米颗粒，并将提高基于荧光的疾病和疾病微生物检测的速度和灵敏度。

Professor Jason McNeill of Clemson University is supported by the Analytical and Surface Chemistry Program to develop novel fluorescent nanoparticles for use in biological detection and imaging. The strategy is to develop core-shell nanoparticle sensors with a highly fluorescent polymer core and a shell that will provide a surface for the attachment of biomolecules such as proteins, antibodies, and DNA. The sensors will be tested using advanced spectroscopy and microscopy techniques. Advanced applications such as monitoring molecular interactions within cells will also be investigated. The educational plan details a well-integrated program to incorporate this research into the education and training of graduate and undergraduate students. The project will result in the dissemination of information about nanomaterials and nanoscience and engineering to the general public. Many tests for disease and pathogens involve the use of fluorescence-based detection schemes. This project will result in fluorescent, polymer-based nanoparticles that are brighter than conventional fluorescent dyes and that will lead to improvements in the speed and sensitivity of fluorescence-based detection of disease and disease microbes.