Molecular mechanisms for seminal fluid signalling in reproduction

男性精液对女性生殖过程的调节影响着人类和动物的生育能力和繁殖力。不育和生殖功能受损是畜牧业的一个主要经济制约因素，并给人类带来巨大的社会和公共卫生成本。本研究将确定精液中活跃的信号分子，并量化它们对生殖成功和后代健康的重要性。研究结果将为开发新的男性生育力诊断方法提供信息，并为在人类健康和动物养殖业中应用的新型生育力治疗和产品的战略设计提供基础。

Male seminal fluid regulation of the female reproductive process influences fertility and fecundity in humans and animal species. Infertility and impaired reproductive function is a major economic constraint in livestock industries, and carries a substantial social and public health cost in humans. This research will identify the active signalling molecules in seminal fluid and quantify their importance in reproductive success and health of offspring. The outcomes will inform development of new diagnostic assays for male fertility, and underpin strategic design of novel fertility treatments and products with applications in the human health and animal breeding industries.