Functional dissociation of octopamine and tyramine receptors in regulationg honey bee division of labour

拟议项目的目的是分离章鱼胺和酪胺受体在调节蜜蜂劳动分工中的作用。当前一个重要的假说认为，劳动分工是基于个体对任务相关刺激反应阈值的差异。因此，我们将详细分析胺受体在控制感觉反应中的作用。为了实现这些目标，提出了四个目标。目的1确定章鱼和酪胺受体基因表达之间的关系，章鱼和酪胺滴度在脑室，目的2确定蜜蜂体内章鱼胺和酪胺受体基因表达是否是一种动态的、可逆的社会功能。目的3确定八胺和酪胺受体基因的干扰是否影响蜜蜂的感觉反应阈值和分工。目的4分析社会刺激对蜜蜂分工和生物胺系统的作用。这些实验将揭示八胺和酪胺受体在调节蜜蜂的感觉反应和分工中的相互作用。他们将首次区分单独的章鱼胺和酪胺受体在昆虫社会组织中的作用。

The aim of the proposed project is to dissociate the roles of octopamine and tyramine receptors in regulating division of labour in honey bees. A prominent current hypothesis assumes that division of labour is based on individual differences in response thresholds for task-related stimuli. Therefore, we will analyse in detail the function of the amine receptors in controlling sensory responsiveness. To achieve these goals, four objectives are put forward.OBJECTIVE 1 is to determine the relationships between the expression of octopamine and tyramine receptor genes, octopamine and tyramine titres in brain compartments, sensory response thresholds and division of labour.OBJECTIVE 2 is to determine if octopamine and tyramine receptor gene expression is a dynamic and reversible function of social role in honey bees.OBJECTIVE 3 is to determine if interference with genes encoding for octopamine and tyramine receptors affects sensory response thresholds and division of labour.OBJECTIVE 4 is to analyse the role of social stimuli for division of labour and the biogenic amine system.These experiments will reveal the interplay of octopamine and tyramine receptors in regulating sensory responsiveness and division of labour in honey bees. They will be the first to differentiate the roles of individual octopamine and tyramine receptors in the social organization of insect societies.