Collaborative Research: Development of Chirped-Pulse Fourier Transform Microwave Spectrometers for Applications in Biomolecule Electronic Spectroscopy

在化学研究仪器和设施：仪器开发计划(CRIF：ID)的支持下，匹兹堡大学化学系将在David W.Pratt的指导下开发两台用于生物分子电子光谱应用的啁啾脉冲傅立叶变换微波(CP-FTMW)光谱仪。这项工作将与弗吉尼亚大学主校区化学系的布鲁克斯·H·佩特合作完成。开发工作将涉及使用激光烧蚀源蒸发不稳定分子的研究，建造具有为生物分子旋转光谱优化的同轴几何结构的CP-FTMW 11 GHz光谱仪，以及开发具有成本效益的CP-FTMW光谱仪，其带宽缩减至200 MHz。光谱仪将与激光光源兼容，进行紫外激光-微波双共振光谱分析。这些仪器将用于根据完全分辨的纯转动光谱来确定气相中相对较大的分子的结构和动力学性质。生物感兴趣的构象柔性分子将被特别研究。11 GHz光谱仪将提供给来自国家实验室、工业和其他大学的科学家和学生网络，主要包括本科院校(PUI)。具有成本效益的200 MHz光谱仪将允许研究人员通过在自己的实验室进行实验来充分利用主光谱仪的结果。通过增加这类光谱仪的可获得性，将加强与PUI机构的合作研究。

With support from the Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF:ID) Program, the Department of Chemistry at the University of Pittsburgh will develop under the direction of David W. Pratt two chirped-pulse Fourier transform microwave (CP-FTMW) spectrometers for applications in biomolecule electronic spectroscopy. This work will be done in collaboration with Brooks H. Pate in the Department of Chemistry at the University of Virginia, Main Campus. The development work will involve studies using laser ablation sources to evaporate involatile molecules, construction of a CP-FTMW 11GHz spectrometer with a coaxial geometry optimized for rotational spectroscopy of biomolecules, and development of a cost-effective CP-FTMW spectrometer with a reduced bandwidth operation of 200MHz. The spectrometers will be compatible with laser sources to undertake UV laser-microwave double resonance spectroscopy. These instruments will be used to determine the structural and dynamical properties of relatively large molecules in the gas phase from their fully resolved pure rotational spectra. Conformationally flexible molecules of biological interest will be particularly investigated. The 11GHz spectrometer will be made available to a network of scientists and students from national laboratories, industry, other universities, including principally undergraduate institutions (PUI). The cost effective 200 MHz spectrometer will allow researchers to fully exploit results from the main spectrometer with experiments performed in their own laboratories. By increasing the accessibility of suchspectrometers, collaborative research with PUI institutions will be enhanced.