Mechanics of Blood Flow in Microvessels

摘要提案编号：0625936主要研究者：Bagchi，Prosenjit附属机构：Rutgers University New Brunswick提案标题：微血管中的血流力学知识优点：拟议的建模工作包括细胞聚集，白色血细胞相互作用，复杂的流动几何形状和多粒子流体动力学的影响。重点将是建模红细胞聚集和固液悬浮液，包括其他物理感兴趣的红细胞运输。这项工作将解决一个重要的跨学科兴趣的问题，在模拟多个物理力的细胞作为膜封装的粘性液体，红细胞是感兴趣的细胞。现有的浸入边界方法结合直接数值模拟的应用已经完成，但应用到毛细血管中的红细胞输运的问题是新颖的。模拟将是多尺度的、全三维的、非稳态的，并且其动态变形将被精确地解决。更广泛的影响：该提案有可能增加对人类生理学、细胞的微流体运输和涉及细胞运输的生物技术应用的理解，因此可能广泛地影响社会。提供了一个研究的教育整合计划，包括与本科研究计划以及本科和研究生课程的互动。研究将通过在期刊和会议上发表来传播，代表性不足的少数群体将被招募参加研究。

ABSTRACTProposal Number: 0625936Principal Investigator: Bagchi, ProsenjitAffiliation: Rutgers University New BrunswickProposal Title: Mechanics of Blood Flow in MicrovesselsIntellectual Merit:The proposed modeling work includes the impacts of cell aggregation, white blood cell interactions, complex flow geometry and multi-particle hydrodynamics. The focus will be on modeling red blood cell aggregation and solid-liquid suspensions to include other physics of interest in red blood cell transport. The work will address an issue of significant interdisciplinary interest in modeling multiple physical forces on cells treated as membrane encapsulated viscous liquids, with red blood cells being the cell of interest. The application of existing immersed boundary methods combined with direct numerical simulation has been done but the application to the problem of red blood cell transport in capillaries is novel. The simulations will be multi-scale, fully three dimensional, unsteady and their dynamic deformation will be accurately resolved. Molecular interaction between adjacent cells and between cell and vessel wall will also be modeled by a kinetic approach, and be coupled to the hydrodynamics.Broader Impact:The proposal has the potential to increase the understanding of human physiology, microfluidic transport of cells and biotechnology applications involving cell transport, and as such could broadly impact society. A program of educational integration of the research is provided including interaction with an undergraduate research program and undergraduate and graduate courses. The research will be disseminated through publication in journals and conferences and underrepresented minorities will be recruited into the research.