Lung Deposition of Highly Agglomerated Nanoparticles

皮特·H·麦克默里明尼苏达大学双城分校0646507建议高度聚集的纳米颗粒的肺沉积摘要假设高度聚集的纳米颗粒的肺沉积不同于相同迁移率大小(扩散系数)的球形颗粒的肺沉积。我们将合成在组成和结构上与目前大量生产的纳米颗粒团聚体相似的纳米颗粒团聚体，并将准确测量它们的传输特性(扩散系数、沉积速度、动态迁移率、空气动力学直径)作为其迁移率当量直径的函数。然后，我们将在从口腔延伸到第八代上呼吸道的呼吸系统模型中测量这些颗粒的流动性和大小依赖的沉积。小至3 nm的球形纳米颗粒在同一呼吸道模型中的沉积将被测量，并将这些结果与团聚体的值进行比较，以确定团聚结构是否影响呼吸系统这一部分的沉积。

Peter H McMurryUniversity of Minnesota-Twin CitiesProposal 0646507Lung Deposition of Highly Agglomerated NanoparticlesABSTRACTIt is hypothesized that lung deposition of highly agglomerated nanoparticles differs from that for spherical particles of the same mobility size (diffusivity). We will synthesize nanoparticulate agglomerates that are similar in composition and structure to those that are currently being produced in large volumes, and we will accurately measure their transport properties (diffusion coefficient, sedimentation speed, dynamic mobility,aerodynamic diameter) as a function of their mobility-equivalent diameter. We will thenmeasure the mobility-size-dependent deposition of these particles in models of the respiratory system extending from the mouth through the 8th generation of the upper respiratory tract. Deposition of spherical nanoparticles as small as 3 nm in the same airway models will be measured, and these results will be compared with values for the agglomerates to determine whether or not agglomerate structure affects deposition in this part of the respiratory system.