NER: Nanofabrication of Field-Effect Fluidic Channels for Dynamic Modulation and Multiplexation of High Speed Microfluidic Biosensors

ECCS-0708540J。Zhe，阿克伦大学知识分子优点：本研究的目的是确定动态调制由电场效应聚合物刷改性的微流体通道的阻抗的可行性。 该方法是纳米fabricate场或化学响应聚合物刷到微流体通道的表面上，研究电场效应的I/V特性的聚合物刷改性的微通道和开发动态调制/复用技术的高速生物传感器的应用。 动态通道调制和信号多路复用的使用使得可以从大量通道获取数据，而无需针对每个通道的单独检测电子器件。这对于高速生物测定尤其重要。 成功交付拟议的工作将导致高通量微库尔特计数装置的快速生物测定的微/纳米尺度的生物颗粒。 它还将促进需要在智能纳米通道中进行流量控制的有源纳米器件的开发，例如用于受控药物输送的分子注射器。更广泛的影响：这个项目的概念，活动和结果将被纳入本科和研究生课程。 将为机械工程和化学专业的本科生提供生物传感器高级设计项目。 将招聘本科研究人员在该项目中进行研究，重点是代表性不足的少数民族和妇女。 通过由NSF教育补助金资助的夏季和周六研讨会，中学生，包括有特殊学习障碍的学生及其教师将接触到该项目中开发的尖端纳米技术和生物传感器。 将鼓励中学生探索科学和工程作为未来的职业选择。

ECCS-0708540J. Zhe, University of AkronIntellectual Merits: The objective of this research is to determine the feasibility of dynamic modulation of the impedance of a microfluidic channel modified by electrical-field-effect polymer brushes. The approach is to nanofabricate field or chemical responsive polymer brushes onto the surface of microfluidic channels, investigate the electrical-field-effect I/V characteristics of the polymer brush-modified microchannels and develop dynamic modulation/multiplexing techniques for high speed biosensor applications. The use of dynamic channel modulation and signal multiplexing makes it possible to acquire data from a large number of channels without individual detection electronics for each channel. It is particularly important for high speed bioassays. Successful delivery of the proposed work will lead to high-throughput micro-Coulter counting devices for rapid bioassay of micro/nano scale bioparticles. It will also facilitate the development of active nano devices that require flow control in smart nanochannels, such as molecular syringes for controlled drug delivery. Broader Impacts: The concept, activities, and results from this project will be incorporated into undergraduate and graduate courses. Biosensor senior design projects for undergraduate students in mechanical engineering and chemistry will be offered. Undergraduate researchers will be recruited to conduct research in this project, with an emphasis on underrepresented minorities and women. Through the summer and Saturday workshops funded by an NSF education grant, middle school students, including those with special learning disabilities and their teachers will be exposed to the cutting edge nanotechnology and biosensors developed in this project. The middle school students will be encouraged to explore science and engineering as a future career choice.