One and two-dimensional superheated water chromatographies

佛罗里达州立大学的约翰·多尔西教授和他的团队正在研究过热水作为色谱流动相和反应介质。通过对过热水色谱保留值的热力学和变色研究，他们旨在阐明保留值的机理，提高对该技术的可预测性和理解。由于层析是一种广泛使用的分离技术，而且层析实验经常被用作各种分配过程的模型，因此这样的理解是非常必要的。过热水色谱的使用目前仅限于学术实验室；在该技术被分析实验室接受之前，必须更好地了解基础知识。使用过热水作为流动相有许多优点，例如降低成本、提高分析速度和改进分析物检测。这些优势对于推进“绿色”化学的目标，以及制药业最近对过程分析技术(PAT)的推动可能特别重要。在这里了解到的信息也将影响这种溶剂作为反应介质的使用。与该项目相关的学生在重要的多学科领域获得宝贵的洞察力。

Professor John Dorsey and his group at Florida State University are studying superheated water as a chromatographic mobile phase and reaction medium. Thorough thermodynamic and salvatochromic investigation of retention in superheated water chromatography, they aim to elucidate the retention mechanism and improve predictability and understanding of the technique. Because chromatography is such a widely used separation technique, and because the chromatography experiment is often used as a model for a variety of partitioning processes, such an understanding is highly desirable. Use of superheated water chromatography is currently limited to the academic laboratory; better fundamental understanding is necessary before the technique can be accepted in the analytical laboratory. There are a variety of advantages that are associated with using superheated water as a mobile phase, such as a reduction in cost, increase in analysis speed, and improvements in analyte detection. These advantages could be especially important for furthering the goals of "green" chemistry, and for the recent drive for Process Analytical Technology (PAT) by the pharmaceutical industry. Information learned here will also impact the use of this solvent as a reaction medium. Students associated with this program gain valuable insight into important multidisciplinary areas.