Synthetic and Mechanistic Studies of Organometallic Reagents

有了这个奖项，有机和高分子化学计划支持教授汉斯J.赖希的威斯康星州的大学，其研究目标是重要的有机金属反应的机制的理解。该研究涉及广泛用于形成碳-碳键的主族有机金属化合物。它们还可用于形成碳-X键，因此是在合成化学中具有重要用途的其它有机金属试剂（B、Zn、Ti、Al、Cu、Ce、Sn、Si、P、S、Se和Te）的常见前体。一个新开发的快速注射核磁共振装置将被用来研究有机锂化学的一些方面，目前的知识是非常有限的：个别聚集体的锂试剂的反应性，羰基化合物的反应性，甚至个别构象的羰基化合物太反应性的实验室时间尺度实验（醛，酮，酯，酰胺）进行研究。所提出的溶剂化和螯合的光谱和反应性研究以及产物选择性和速率研究将导致更好地理解这些现象，更好地预测有机锂试剂的化学反应，并扩大锂试剂的应用。有机和高分子化学项目支持威斯康星州大学的Hans J.赖希教授，他的研究将在以下领域产生影响：合成有机化学通过提供更好的洞察重要的反应物种的行为。该研究将通过为研究生和本科生提供物理有机化学，有机金属化学，光谱学和有机合成方面的广泛培训，为科学人才做出贡献。两个通用的NMR数据的分析和解释的计算机程序和化学信息的有效呈现已经编写，以支持这项研究，并将继续得到加强。这些程序已在网上免费提供给化学界。已经建立了几个网站，其中以方便查阅的形式提供了与有机和有机金属化学有关的宝贵信息，这些网站将在本项目执行过程中继续扩大和加强。

With this award, the Organic and Macromolecular Chemistry Program supports Professor Hans J. Reich of the University of Wisconsin whose research goal is a mechanism understanding of important organometallic reactions. The study involves main group organometallic compounds that are widely used for forming carbon-carbon bonds. They are also useful for forming carbon-X bonds and are, therefore, common precusors to other organometallic reagents (B, Zn, Ti, Al, Cu, Ce, Sn, Si, P, S, Se and Te) with important uses in synthetic chemistry. A newly developed rapid injection NMR apparatus will be used to study a number of aspects of organolithium chemistry for which current knowledge is very limited: the reactivity of individual aggregates of lithium reagents, the reactivity of carbonyl compounds, and even individual conformations of carbonyl compounds too reactive to be studied by laboratory time scale experiments (aldehydes, ketones, esters, amides). The proposed spectroscopic and reactivity studies of solvation and chelation together with product selectivity and rate studies will result in a better understanding of these phenomena, better predictability of the chemical reactions of organolithium reagents, and expansion of the applications of lithium reagents.With this award, the Organic and Macromolecular Chemistry Program supports Professor Hans J. Reich of the University of Wisconsin whose research will have an impact in the area of synthetic organic chemistry by providing better insight into the behavior of important reactive species. The research will contribute to scientific manpower by providing a broad training in physical organic chemistry, organometallic chemistry, spectroscopy and organic synthesis for graduate and undergraduate students. Two computer programs of general utility for the analysis and interpretation of NMR data and the efficient presentation of chemical information have been written to support this research, and will continue to be enhanced. These programs have been made freely available to the chemical community on the web. Several web sites containing valuable information related to organic and organometallic chemistry in an easily accessible form have been created, and these will continue to be expanded and enhanced in the course of this project.