Rapid Injection NMR Studies of Copper(I) and Copper(III) Organocuprates

有了这个奖项，有机和大分子化学项目支持北卡罗莱纳大学夏洛特分校的Craig A. Ogle和Michael D. Murphy教授，他们将应用核磁共振波谱和快速注射核磁共振（RINMR）技术来研究有机铜化合物的反应，这些反应是形成C-C键的一些最有价值的试剂。以前，在有机酸盐化学中已经发现了几个长期寻找的铜（III）中间体。它们已被表征并证明是有机酸盐反应化学中的中间体。在找到制备中间体的方法后，将探讨铜（III）化合物的反应化学。传统上，铜(I)铜酸盐具有丰富的合成化学，预计这些铜（III）铜酸盐可能具有非常丰富的合成化学。将探索制备这些铜（III）化合物的新方法，使用快速注射核磁共振进行后续反应，以及它们的台式化学反应。继续深入了解这些反应的机理，将使有机羧酸盐的烷基化更有效，副反应更少，从而改进这些反应，并可能导致对试剂和反应条件进行合理改变的新方法，从而使它们能够被对端选择性地控制。这项来自有机和大分子化学项目的奖项支持了北卡罗来纳大学夏洛特分校的Craig a . Ogle和Michael D. Murphy教授，他们的研究将探索铜（III）铜酸盐的化学性质，铜酸盐是迄今为止大部分未知的一类化合物，但对于合成化学家来说，从常见的前体中很容易获得。克雷格教授和墨菲教授将继续与工业科学家合作，使用RINMR技术。本项目将对本科生和研究生进行气敏试剂制备与处理、分析仪器操作、实验设计等方面的培训。学生也将有机会分析核磁共振光谱和动力学数据，与工业化学家互动，并在地区和国家会议上展示他们的数据。这项研究的经济影响可能是重大的，可能会导致制药业的新产品和新方法。

With this award, the Organic and Macromolecular Chemistry Program supports Professors Craig A. Ogle and Michael D. Murphy of the University of North Carolina- Charlotte who will apply NMR spectroscopy and the rapid injection NMR (RINMR) technique to study the reactions of organocopper compounds, which are some of the most valuable reagents for the formation of C-C bonds. Previously, several long sought after copper (III) intermediates in organocuprate chemistry have been identified. These have been characterized and shown to be intermediates in organocuprate reaction chemistry. Having found ways of preparing the intermediate, the reaction chemistry of copper (III) compounds will be explored. Traditionally, copper (I) cuprates have a rich synthetic chemistry and it is expected that there may be a very rich synthetic chemistry associated with these copper(III) cuprates. New ways ofpreparing these copper (III) compounds, their subsequent reactions using rapid injection NMR, and their bench-top chemistry will be explored. Continuing to understand these reactions at a deep mechanistic level will improve them by making the alkylation of organocuprates more efficient with less side reactions and may lead to new ways of making rational changes to the reagents and reaction conditions to allow them to be controlled enantioselectively. .This award from the Organic and Macromolecular Chemistry Program supports Professors Craig A. Ogle and Michael D. Murphy of the University of North Carolina- Charlotte whose research will explore the chemistry of copper(III) cuprates, a class of compounds that up until now were largely unknown but should be readily available to the synthetic chemist from common precursors. Professors Craig ands Murphy will continue their collaboration using the RINMR technique with industrial scientists. This project will offer the training of undergraduate and graduate students in the preparation and handling of air sensitive reagents, operation of analytical instrumentation, and experimental design. Students will also have opportunities to analyze NMR spectra and kinetic data, interact with an industrial chemist, and present their data at regional and national meetings. The economic impact of this research could be significant, potentially leading to new products and methodologies in the pharmaceutical industry.