CONFERENCE: 2007 Enzymes, Co-Enzymes, and Metabolic Pathways Gordon Conference to be held in Biddeford, Maine on July 8-13, 2007

关于酶、辅酶和代谢途径的戈登研究会议成立于1963年，作为聚集机械和代谢生物化学领域最优秀的人才的工具，讨论该领域的新进展，并揭示管理当时蓬勃发展的学科的基本规则。当时，主要的重点是了解酶的催化和调节原理，以及阐明主要的代谢途径。现在，25年后的今天，酶学领域对与成键和断键有关的极性机制进行的酶反应有了深刻的了解，对常见的有机辅因子如黄素腺嘌呤二核苷酸、烟酰胺腺嘌呤二核苷酸、硫胺素二磷酸、生物素和硫辛酸的功能也有了坚实的了解。尽管在这些领域仍然存在令人兴奋和重要的问题，但焦点和势头现在正在转移到新的前沿，例如了解酶如何通过涉及未配对电子的机制催化反应，以及在体内研究酶反应及其组成的路径。这一资金申请的更广泛影响是，这次会议将为所有职业阶段和从事与会议主题相关的不同生物化学领域的科学家提供一个论坛，以聚集和讨论该领域的前沿问题。就这项提议的更广泛影响而言，首要目标是为处于职业生涯早期的科学家提供一个建立网络并讨论在这一科学领域取得成功的战略的机会。

The Gordon Research Conference on Enzymes, Co-enzymes, and Metabolic Pathways was established in 1963 as a vehicle for assembling the best minds in the field of mechanistic and metabolic biochemistry to discuss new advances in the field and uncover the fundamental rules that govern a then blossoming discipline. At the time, the major emphases were on understanding the principles of enzyme catalysis and regulation, and elucidating primary metabolic pathways. Now, twenty-five years later, the field of enzymology enjoys a strong understanding of enzymatic reactions that proceed by polar mechanisms as they pertain to bond making and bond breaking, as well as a solid understanding of the function of common organic cofactors such as flavin adenine dinucleotide, nicotinamide adenine dinucleotide, thiamin diphosphate, biotin, and lipoic acid. Although there are yet exciting and important issues remaining in these areas, focus and momentum are now shifting towards new frontiers, such as understanding how enzymes catalyze reactions that proceed via mechanisms that involve unpaired electrons, and the in vivo study of enzymatic reactions and the pathways that they compose. The broader impact of this request for funding is that this conference will provide a forum for scientists at all career stages and working in diverse areas of biochemistry that are related to the themes of the conference to assemble and discuss issues at the frontier of the field. The overarching goal with respect to the broader impacts of this proposal is to provide an opportunity for scientists at an early stage in their careers to network and discuss strategies for success in this area of science.