Development of a Microfabricated, Coded Aperture Mass Spectrometer

目的：本提案的目标是制定一个？编码孔径微质谱仪？用于无处不在的环境危害、化学战剂和生化标记物的实时检测。这将通过结合离子源和探测器的新型微加工技术与编码孔径光学和算法来实现。这种微型质谱仪的实现将使一种新的传感模式成为可能，它同时提供高灵敏度和探测广泛物种的能力。智力价值：所提议的工作的智力价值包括通过确认其在离子基系统中的价值和开发磁扇区质谱法的算法来推进编码孔径光谱技术的发展。确定离子与编码孔径的相互作用并优化这种离子基系统的算法也对离子基系统中计算传感的未来工作具有科学意义。更广泛的影响：这项研究将对未来几代离子基仪器产生广泛的影响，这些仪器希望提高吞吐量和信噪比。离子编码的概念不限于任何一种形式的光谱和适用于所有粒子的质量和/或电荷。这项拟议的研究对研究生和本科生的教育影响也将非常高。这是一个真正的多学科的努力，需要理解电气工程，物理，材料科学和化学；因此，这是对未来科学家的极好训练。它将利用杜克大学的普拉特研究员项目，为本科生带来研究经验。

Objective:The goal of this proposal is to develop a ?Coded Aperture Micro Mass Spectrometer? for ubiquitous real-time detection of environmental hazards, chemical warfare agents and biochemical markers. This will be accomplished by combining novel microfabrication technologies for ion sources and detectors with coded aperture optics and algorithms. Achievement of such a micro mass spectrometer will enable a new paradigm of sensing which simultaneously provides high sensitivity and the ability to detect a broad range of species.Intellectual Merit:The intellectual merit of the proposed work includes advancing the state of the art of coded aperture spectroscopy by confirming its value in ion-based systems and developing algorithms for magnetic sector mass spectrometry. Determining the interaction of ions with coded apertures and optimizing the algorithms for such an ion-based system also holds scientific interest for future work in computational sensing in ion based systems. Broader Impact:This research will have broad impact on future generations of ion-based instruments which desire throughput and S/N enhancements. The ion coding concepts are not limited to any one form of spectrometry and apply to all particles with mass and/or charge. The educational impact of this proposed research will also be very high for both graduate and undergraduate students. It is a truly multidisciplinary effort requiring an understanding of electrical engineering, physics, materials science and chemistry; thus, it is excellent training for future scientists. It will leverage the Pratt fellows program at Duke to bring research experiences to undergraduate students.