Exploiting Oxetanes with alpha-Unsaturation

本项目的重点是进一步探索2-亚甲基氧杂环丁烷、1，5-二氧杂螺[3.2]己烷、4-氧杂螺[2.3]己烷和3-亚烷基-2-亚甲基氧杂环丁烷等具有活性的杂环化合物。 改进获得一系列3-亚烷基-2-亚甲基氧杂环丁烷将允许初步检查这些化合物作为脂肪酸脱氢酶抑制剂的效用。 初步研究表明，可以通过这种方法获得可用作抗病毒或抗菌剂的新型含氧杂环丁烷核苷。此外，一个新的，机械有趣的方法，有用的官能化四氢呋喃将被调查。有了这个奖项，有机和大分子化学计划是支持教授艾米R。康涅狄格大学化学系的豪厄尔说。 豪厄尔教授的研究工作围绕着利用不寻常的，紧张的杂环作为有效的有机合成支架。 这种化学将有助于制备新颖的、具有生物学意义的小分子，并将对制药和农业部门产生影响。

This project is centered on the further exploration of 2-methyleneoxetanes, 1,5-dioxa-spiro[3.2]hexanes, 4-oxaspiro[2.3]hexanes and 3-alkylidene-2-methyleneoxetanes, strained heterocycles with useful reactivities. Improved access to a range of 3-alkylidene-2-methyleneoxetanes will allow preliminary examination of the utility of these compounds as inhibitors of fatty acid synthases. Initial studies have shown that novel, oxetane-containing nucleosides, which may serve as anti-viral or anti-bacterial agents, can be accessed with this methodology. In addition, a new, mechanistically interesting approach to usefully functionalized tetrahydrofurans will be investigated.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Amy R. Howell of the Department of Chemistry at the University of Connecticut. Professor Howell's research efforts revolve around exploiting unusual, strained heterocycles as scaffolds for efficient organic synthesis. Such chemistry will contribute to the preparation of novel, biologically interesting small molecules and will have an impact on the pharmaceutical and agricultural sectors.