Chiral Porous Materials for Enantioselective Catalysis and Separations

这一无机化学、生物无机化学和金属有机化学奖支持了北卡罗来纳大学林文斌教授的研究，该研究旨在开发合理的合成策略，以获得同手性和高孔性的金属-有机配位网络(MOCN)，并探索它们在多相不对称催化和手性分离中的应用。基于同手性多孔碳纳米管的多相不对称催化剂的三个关键问题是：合理地合成具有永久孔隙率和适当官能度的同手性多壁碳纳米管，开发从典型的不可拆分的(非手性)构件合成高孔的同手性多壁碳纳米管的新策略，以及同手性多孔碳纳米管在实际的对映选择性催化和分离中的应用。这项研究将产生具有理想官能团和适当金属连接物的高度多孔的手性碳纳米管，它应该具有可裁剪的手性口袋和可用于对映体选择性分离和催化的功能。拟议的研究将开发新的自下而上的方法来开发高效的多相不对称催化剂，这些催化剂可以很容易地回收和重复使用，并可以防止往往有毒的金属从催化剂中浸出到有机产品中。参与拟议跨学科研究的研究生和博士后研究助理将接受培训，掌握对他们未来的博士化学家职业生涯至关重要的技能。拟议的研究还将纳入本科生和高中生的培训。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Wenbin Lin at the University of North Carolina to develop rational synthetic strategies toward homochiral and highly porous metal-organic coordination networks (MOCNs) and to explore their applications in heterogeneous asymmetric catalysis and chiral separations. Three key issues concerning heterogeneous asymmetric catalysts based on homochiral porous MOCNs will be addressed: rational synthesis of homochiral MOCNs with permanent porosity and appropriate functionalities, development of novel strategies for the synthesis of highly porous homochiral MOCNs from typically unresolvable (achiral) building blocks, and the utilities of homochiral porous MOCNs in practical enantioselective catalysis and separations. Highly porous chiral MOCNs with desirable functional groups and appropriate metal linkers will result from the proposed research, which should possess tailorable chiral pockets and functionalities that are exploitable for enantioselective separations and catalysis. The proposed research will develop new bottom-up approaches towards efficient heterogeneous asymmetric catalysts that can be readily recycled and re-used and can prevent the leaching of often toxic metals from the catalysts into the organic products. Graduate students and postdoctoral research associates participating in the proposed interdisciplinary research will be trained with the skills that are crucial to their future careers as Ph.D. chemists. The proposed research will also be integrated into the training of undergraduates and high school students.