MRI: Acquisition of a 200 kV Electron Tomography Microscope for Quantitative High Resolution Imaging of Cells in 3 Dimensions

耶鲁大学医学院获得了一笔赠款，用于购买电子断层扫描显微镜，用于细胞和纳米材料的三维（3D）定量高分辨率成像。凭借其令人印象深刻的高分辨率（~5纳米），新显微镜将使厚生物切片和其他物体的体积可视化成为可能，并将被耶鲁大学11个系的17个实验室使用。具体的重点领域将包括神经元和突触的高分辨率成像，囊泡交通，细胞骨架和纳米材料，以及新的图像分析方法的开发。这笔赠款将在耶鲁大学科学界和超越产生广泛的影响。它将帮助培养学生和博士后研究员强大的新成像技术，建立跨学科的新合作，将不同背景的科学家聚集在一起，与私营部门建立新的伙伴关系，开发分析和挖掘断层扫描数据集的方法，并提供一个强大的教育和推广计划到当地社区（通过链接到当地高中和耶鲁大学？星星？SURF，Biostep程序）。 在所有这些方面，该奖项将支持耶鲁大学和国家科学基金会的科学，教育和多样性目标。

A grant has been awarded to Yale University School of Medicine to acquire an electron tomography microscope for quantitative high-resolution imaging of cells and nanomaterials in three dimensions (3D). With its impressive high resolution (~5 nanometers) the new microscope will make it possible to visualize thick biological sections and other objects volumetrically, and will be used by more than 17 laboratories from 11 Yale departments. Specific focus areas will include high-resolution imaging of neurons and synapses, vesicular traffic, cytoskeleton, and nanomaterials, as well as the development of new methods of image analysis.The grant will have a broad impact in the Yale scientific community and beyond. It will help train students and postdoctoral fellows in powerful new imaging techniques, forge new collaborations across discipline boundaries, bring scientists from diverse backgrounds together, create new partnerships with the private sector, develop methodology to analyze and mine tomography datasets, and provide a strong program for education and outreach to the local community (via links to local high schools and Yale ?STARS?, SURF, Biostep programs). In all of these ways, the award will support the scientific, educational, and diversity aims of Yale University and the National Science Foundation.