BRIGE Proposal: Nano-pattern modified microelectrodes for the improvement of continuous in vitro glucose monitoring detection.

[0824288] gymama Slaughter，弗吉尼亚州立大学，bridge：纳米模式修饰的微电极用于改善连续体外血糖监测检测[摘要]该提案是对工程拓宽参与研究启动基金（bridge）征求的回应，NSF 07-589。其智力优势在于将K-16教育成功的教学技术融入到弗吉尼亚州立大学工程与技术研究环境中。该项目基于跨学科的研究和开发计划，重点是用于治疗药物监测的安培生物传感器的设计、制造和体外表征。该生物传感器设计集成了软凝聚、生物智能水凝胶和固态微制造电极，以及酶和纳米微电极的耦合。此外，本研究将结合本科生、高中生和教师的实证实验和研究经验。该研究将引入新兴的生物传感器技术，让本科生、高中生和教师接触到研究经验和实用的仪器方法，从而为创建和整合有效的现代教学方法（团队合作和经验学习等）提供机会。更广泛的影响在于目前工程研究和教育之间的脱节，这可能会通过外展项目开发灵活的课程来弥补，比如里士满地区工程少数民族项目。在这个正在进行的项目中，高中教师将能够利用他们的研究经验，在他们的家乡学校开展更有效的生命科学工程工作。学校已经尽一切努力从代表性不足的群体中招收学生，以确保人才的多样化。利用里士满地区工程少数民族项目开展的研究将在PI的网站上随时提供，以便其他机构可以使用（和修改），从而促进合作。拟议的工作将通过生成便于许多机构携带的研究材料来加强基础设施。研究结果将在国家社会会议上以及在PI的网站上发布。此外，研究结果将发表在传统的同行评议期刊上。

0824288Gymama Slaughter, Virginia State UniversityBRIGE: Nano-Pattern Modified Microelectrodes for the Improvement of Continuous in Vitro Glucose Monitoring DetectionAbstractThis proposal was received in response to the Broadening Participation Research Initiation Grants in Engineering (BRIGE) solicitation, NSF 07-589. The intellectual merit lies in the integration of successful pedagogical techniques from K-16 education into the Virginia State University, Department of Engineering & Technology environment of research. The project is based on an interdisciplinary research and development plan focusing on the design, fabrication, and in-vitro characterization of an amperometric biosensor for therapeutic drug monitoring. The biosensor design integrates soft-condensed, bio-smart hydrogels with solid-state microfabricated electrodes, and coupling of enzymes and nano-pattern microelectrodes. Furthermore, empirical experimentation and research experience for undergraduates, high school students, and teachers will be coalesce in the proposed work. The research will introduce emerging biosensor technology, expose undergraduates, high school students, and teachers to research experiences and practical instrumentation methods, hence providing the opportunity to create and incorporate effective modern teaching methods (team-based and experience-based learning, etc.) into the proposed research.The broader impacts lie in the current disconnect between engineering research and education, which may be bridged by the development of a flexible curriculum through outreach programs, such as the Richmond Area Program for Minorities in Engineering. In this ongoing project, the high school teachers will be equipped to build on their research experience to develop even more effective Life Science Engineering efforts in their home school. Every effort has already been made to recruit students from under-represented groups to ensure a diverse range of talents. The research developed by utilizing Richmond Area Program for Minorities in Engineering will be made readily available on the PI's web site, so that it may be utilized (and modified) by other institutions, thus fostering collaboration. The proposed work will enhance infrastructure through the generated research materials that are easily portable to many institutions. Findings of the research will be disseminated at national societal conferences as well as on the PI's web site. Additionally, results will be published in traditional peer-reviewed journals.