Multiscale Coarse-Grained Modeling with Experimental Verification of DNA-Carbon Nanotube Complexes

本项目的研究目标是通过综合实验和建模方法揭示碳纳米管（CNTs）与DNA分子之间潜在的相互作用机制。DNA- cnt复合物得益于碳纳米管独特的机电性能和固定化单链DNA的特定分子识别能力，在生物分子检测和基因传递应用中具有很大的前景。尽管之前进行了大量的实验工作，但dna -碳纳米管界面仍然知之甚少，这极大地限制了这种新应用的可靠性和效率。这项研究将大大提高我们目前对dna -碳纳米管界面的认识，并将为实现高灵敏度小型化的基于dna -碳纳米管的生物传感器铺平道路。补充教育计划将大大提高公众对基于纳米技术的生物医学应用的认识，并促进年轻研究人员参与纳米生物技术这一激动人心的领域。

The research goal of this project is to uncover the underlying interaction mechanisms between carbon nanotubes (CNTs) and DNA molecules through an integrated experimental and modeling approach. DNA-CNT complexes, benefiting from both the unique electro-mechanical properties of CNTs and the specific molecular recognition capabilities of the immobilized single-stranded DNA, hold great promise for bio-molecular detection and gene delivery applications. Despite considerable prior experimental efforts, the DNA-CNT interface is still poorly understood, greatly limiting the reliability and the efficiency of such novel applications.This research will significantly enhance our current knowledge of the DNA-CNT interface, and will pave the way toward the realization of high-sensitivity miniaturized DNA-CNT based biosensors. The complementary educational plan will greatly increase both the general public's awareness of nanotechnology-based biomedical applications and the participation of young investigators in the exciting field of nanobiotechnology.